SFRP1 encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: frizzled-related protein; FRP; FRP-1; FRP1; FrzA; SARP-2; SARP2; Secreted apoptosis-related protein 2; Secreted frizzled-related protein 1; sFRP-1
Gene Aliases: FRP; FRP-1; FRP1; FrzA; SARP2; SFRP1
UniProt ID: (Human) Q8N474
Entrez Gene ID: (Human) 6422