Immunogen sequence: LKSEAIIEHLC ASEFALRMKI KEVKKENGDK KIVPKKKKPL KLGPIKKKDL
Highest antigen sequence identity to the following orthologs - mouse 98%, rat 88%.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
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Protein Aliases: frizzled-related protein; FRP; FRP-1; FRP1; FrzA; SARP-2; SARP2; Secreted apoptosis-related protein 2; Secreted frizzled-related protein 1; sFRP-1; SFRP1
Gene Aliases: FRP; FRP-1; FRP1; FrzA; SARP2; SFRP1
UniProt ID: (Human) Q8N474
Entrez Gene ID: (Human) 6422