Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This antibody got 41-51 kDa and 55 kDa bands in western blotting maybe due to differential posttranslational protein modification.
Immunogen sequence: MFLSILVAL CLWLHLALGV RGAPCEAVRI PMCRHMPWNI TRMPNHLHHS TQENAILAIE QYEELVDVNC SAVLRFFLCA MYAPICTLEF LHDPIKPCKS VCQRARDDCE PLMKMYNHSW PESLACDELP VYDRGVCISP EAIVTDLPED VKWIDITPDM MVQERPLDVD CKRLSPDRCK CKKVKPTLAT YLSKNYSYVI HAKIKAVQRS GCNEVTTVVD VKEIFKSSSP IPRTQVPLIT NSSCQCPHIL PHQDVLIMCY EWRSRMMLLE NCLVEKWRDQ LSKRSIQWEE RLQEQRRTVQ DKKKTAGRTS RSNPPKPKGK PPAPKPASPK KNIKTRSAQK RTNPKRV (1-346 aa encoded by BC058911)
Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular domain Frizzled proteins use for the binding of Wnt proteins and receptors. Lacking the transmembrane and intracellular domains of the Frizzled proteins, sFRPs function as soluble modulators of the Wnt signaling pathway through the direct binding of Wnt proteins to this cysteine-rich domain, and the resultant inhibition of Wnt receptor binding and signaling capabilities. sFRP-4 is widely distributed in a variety of embryonic and adult tissues where it can function as a circulating antiangiogenic factor, a potent proapoptotic factor, an inhibitor of insulin secretion, and a suppressor of both tumor growth and metastatic potential through disruption of the Wnt signaling pathway. Research has demonstrated the existence of a direct correlation between the downregulation and/or absence of circulating sFRP-4 and the progression of several cancer types, including ovarian, endometrial, prostate and lung. Upregulation of circulating sFRP-4 has been linked to the deterioration of glucose metabolism in the case of type 2 diabetes, as well as the suppression of the keratinocyte hyperproliferation and epidermal hyperlasia that are definitive of psoriasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support