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Proteintech
SFRP4 Polyclonal Antibody
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Product Details
15328-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SFRP4 Fusion Protein Ag6909 (1-346 aa encoded by BC058911)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody got 41-51 kDa and 55 kDa bands in western blotting maybe due to differential posttranslational protein modification.
Immunogen sequence: MFLSILVAL CLWLHLALGV RGAPCEAVRI PMCRHMPWNI TRMPNHLHHS TQENAILAIE QYEELVDVNC SAVLRFFLCA MYAPICTLEF LHDPIKPCKS VCQRARDDCE PLMKMYNHSW PESLACDELP VYDRGVCISP EAIVTDLPED VKWIDITPDM MVQERPLDVD CKRLSPDRCK CKKVKPTLAT YLSKNYSYVI HAKIKAVQRS GCNEVTTVVD VKEIFKSSSP IPRTQVPLIT NSSCQCPHIL PHQDVLIMCY EWRSRMMLLE NCLVEKWRDQ LSKRSIQWEE RLQEQRRTVQ DKKKTAGRTS RSNPPKPKGK PPAPKPASPK KNIKTRSAQK RTNPKRV (1-346 aa encoded by BC058911)
Target Information
Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular domain Frizzled proteins use for the binding of Wnt proteins and receptors. Lacking the transmembrane and intracellular domains of the Frizzled proteins, sFRPs function as soluble modulators of the Wnt signaling pathway through the direct binding of Wnt proteins to this cysteine-rich domain, and the resultant inhibition of Wnt receptor binding and signaling capabilities. sFRP-4 is widely distributed in a variety of embryonic and adult tissues where it can function as a circulating antiangiogenic factor, a potent proapoptotic factor, an inhibitor of insulin secretion, and a suppressor of both tumor growth and metastatic potential through disruption of the Wnt signaling pathway. Research has demonstrated the existence of a direct correlation between the downregulation and/or absence of circulating sFRP-4 and the progression of several cancer types, including ovarian, endometrial, prostate and lung. Upregulation of circulating sFRP-4 has been linked to the deterioration of glucose metabolism in the case of type 2 diabetes, as well as the suppression of the keratinocyte hyperproliferation and epidermal hyperlasia that are definitive of psoriasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Frizzled protein, human endometrium; frizzled related protein; FrpHE; MGC26498; Secreted frizzled-related protein 4; secreted frizzled-related protein 4; secreted frizzled-related protein 4; sFRP-4; SFRP4; unnamed protein product
Gene Aliases: FRP-4; FRPHE; FRZB-2; PYL; sFRP-4; SFRP4
UniProt ID: (Human) Q6FHJ7
Entrez Gene ID: (Human) 6424
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
positive regulation of receptor internalization
negative regulation of cell proliferation
response to hormone
organ morphogenesis
positive regulation of gene expression
Wnt signaling pathway
cell differentiation
negative regulation of Wnt signaling pathway
regulation of BMP signaling pathway
non-canonical Wnt signaling pathway
positive regulation of apoptotic process
positive regulation of epidermal cell differentiation
phosphate ion homeostasis
canonical Wnt signaling pathway
bone morphogenesis
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of keratinocyte apoptotic process
negative regulation of non-canonical Wnt signaling pathway
negative regulation of sodium-dependent phosphate transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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