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Invitrogen
SFTPC Polyclonal Antibody
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FIGURE: 1 / 3
SFTPC Antibody (PA5-102493) in ICC/IF
Immunocytochemistry analysis of SFTPC in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SFTPC polyclonal antibody (Product # PA5-102493) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-102493
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SFTPC(Accession P11686), corresponding to amino acid residues M1-K34.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SP-C.
Target Information
This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BRICHOS domain containing 6; PSP C; pulmonary surfactant apoprotein-2 SP-C; Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated proteolipid SPL(Val); SFTP 2; SP C; SP-C; SP5; surfactant associated protein C; Surfactant protein C; Surfactant pulmonary-associated protein C; Surfactant, pulmonary-associated protein C
Gene Aliases: BRICD6; pro-SpC; PSP-C; Sftp-2; SFTP2; SFTPC; SMDP2; SP-C; SP5; SPC
UniProt ID: (Human) P11686, (Rat) P11685
Entrez Gene ID: (Human) 6440, (Mouse) 20389, (Rat) 50683
respiratory gaseous exchange
cellular protein metabolic process
protein homooligomerization
circadian rhythm
response to hormone
response to glucose
response to organic substance
response to lipopolysaccharide
response to retinoic acid
response to vitamin A
regulation of liquid surface tension
response to glucocorticoid
response to cAMP
response to hyperoxia
response to interleukin-6
response to growth factor
cellular response to mechanical stimulus
cellular response to nitric oxide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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