Immunogen sequence: MKEVVYWSPK KVADWLLENA MPEYCEPLEH FTGQDLINLT QEDFKKPPLC RVSSDNGQRL LDMIETLKME HHLEAHKNGH ANGHLNIGVD IPTPDGSFSI KIKPNGMPNG YRKEMIKIPM PELERSQYPM EWGK; Positive Samples: A-549; Cellular Location: Golgi apparatus membrane, Multi-pass membrane protein
A bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and the inverse reaction. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. May not function strictly as a SM synthase. Inhibited by bacterial PC-phospholipase C inhibitor D609. Localized to Golgi apparatus; Golgi membrane; multi-pass membrane protein. Possibly present on Brain, heart, kidney, liver, muscle and stomach.
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Protein Aliases: Medulla oblongata-derived protein; MGC17342; mob-1; Phosphatidylcholine:ceramide cholinephosphotransferase 1; Protein Mob; Sphingomyelin synthase 1; Transmembrane protein 23
Gene Aliases: hmob33; MOB; MOB1; SGMS1; SMS1; TMEM23