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Invitrogen
SGMS1 Polyclonal Antibody
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Product Details
PA5-90177
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human SGMS1 (NP_6715121)
Conjugate
Form
Liquid
Concentration
1.9 mg/mL
Amount
190 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MKEVVYWSPK KVADWLLENA MPEYCEPLEH FTGQDLINLT QEDFKKPPLC RVSSDNGQRL LDMIETLKME HHLEAHKNGH ANGHLNIGVD IPTPDGSFSI KIKPNGMPNG YRKEMIKIPM PELERSQYPM EWGK; Positive Samples: A-549; Cellular Location: Golgi apparatus membrane, Multi-pass membrane protein
Target Information
A bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and the inverse reaction. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. May not function strictly as a SM synthase. Inhibited by bacterial PC-phospholipase C inhibitor D609. Localized to Golgi apparatus; Golgi membrane; multi-pass membrane protein. Possibly present on Brain, heart, kidney, liver, muscle and stomach.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Medulla oblongata-derived protein; MGC17342; mob-1; Phosphatidylcholine:ceramide cholinephosphotransferase 1; Protein Mob; putative transmembrane protein; Sphingomyelin synthase 1; transmembrane protein; Transmembrane protein 23; unnamed protein product
Gene Aliases: hmob33; MOB; MOB1; SGMS1; SMS1; TMEM23
UniProt ID: (Human) Q86VZ5, (Rat) Q7TSX5
Entrez Gene ID: (Human) 259230, (Rat) 353229
lipid metabolic process
sphingolipid metabolic process
sphingomyelin biosynthetic process
apoptotic process
sphingolipid biosynthetic process
ceramide biosynthetic process
regulation of intrinsic apoptotic signaling pathway
inflammatory response
positive regulation of gene expression
cell growth
phosphorylation
cellular response to lipopolysaccharide
cellular response to tumor necrosis factor
negative regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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