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Proteintech
SGOL1 Polyclonal Antibody
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Product Details
16977-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SGOL1 Fusion Protein Ag9700 (1-292 aa encoded by BC017867)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAKERCLKK SFQDSLEDIK KRMKEKRNKN LAEIGKRRSF IAAPCQIITN TSTLLKNYQD NNKMLVLALE NEKSKVKEAQ DIILQLRKEC YYLTCQLYAL KGKLTSQQTV EPAQNQEICS SGMDPNSDDS SRNLFVKDLP QIPLEETELP GQGESFQIEA TPPETQQSPH LSLKDITNVS LYPVVKIRRL SLSPKKNKAS PAVALPKRRC TASVNYKEPT LASKLRRGDP FTDLCFLNSP IFKQKKDLRR SKKRALEVSP AKEAIFILYY VREFVSRFPD CRKCKLETHI CLR (1-292 aa encoded by BC017867)
Target Information
The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles. Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life. Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hSgo1; Serologically defined breast cancer antigen NY-BR-85; Shugoshin 1; shugoshin 1A protein; shugoshin 1AB protein; shugoshin 1CD protein; shugoshin 1EF protein; shugoshin 1GH protein; shugoshin 1KL protein; Shugoshin-like 1; shugoshin-like 1 (S. pombe)
Gene Aliases: 3300001M08Rik; C81037; CAID; NY-BR-85; SGO; SGO1; SGOL1
UniProt ID: (Human) Q5FBB7, (Mouse) Q9CXH7
Entrez Gene ID: (Human) 151648, (Rat) 363174, (Mouse) 72415
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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