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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:400 | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Bovine, Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide corresponding to sphingosine 1-phosphate lyase 1. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1.0 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.08% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2285994 |
By Western blot, PA1-12722 detects a ~64 kDa protein representing S1P lyase 1 from MDBK cell lysate.
Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1 phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1- phosphate lyase converts sphingosine 1-phosphate to phosphoethanolamine and palmitaldehyde using Pyridoxal phosphate as a co-factor. Sphingosine 1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum. Sphingosine 1-phosphate lyase is found primarily in the liver and kidney. Sphingosine 1-phosphate lyase belongs to the group II decarboxylase family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ13811; hSPL; mSPL; S1PL; SP-lyase 1; sphingosine phosphate lyase 1; Sphingosine-1-phosphate aldolase; Sphingosine-1-phosphate lyase 1; SPL 1
Gene Aliases: AI428538; D10Xrf456; KIAA1252; S1PL; SGPL1; Spgl1; SPL
UniProt ID: (Human) O95470, (Mouse) Q8R0X7, (Rat) Q8CHN6
Entrez Gene ID: (Human) 8879, (Bovine) 522515, (Mouse) 20397, (Rat) 286896
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