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Proteintech
SH2D1A Polyclonal Antibody
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Product Details
11868-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SH2D1A Fusion Protein Ag2450 (1-128 aa encoded by BC020732)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDAVAVYHG KISRETGEKL LLATGLDGSY LLRDSESVPG VYCLCVLYHG YIYTYRVSQT ETGSWSAETA PGVHKRYFRK IKNLISAFQK PDQGIVIPLQ YPVEKKSSAR STQGTTGIRE DPDVCLKAP (1-128 aa encoded by BC020732 )
Target Information
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Duncan disease homolog; Duncan disease SH2-protein; Duncan's disease; FLJ18687; FLJ92177; HGNC:10820; RP5-1052M9.3; SAP; SH2 domain protein 1A; SH2 domain-containing protein 1A; SH2D1A; signaling lymphocyte activation molecule-associated protein; Signaling lymphocytic activation molecule-associated protein; SLAM associated protein/SH2 domain protein 1A; SLAM-associated protein; SLAM-associated protein isoform SAP-2; T cell signal transduction molecule SAP; T-cell signal transduction molecule SAP; unnamed protein product
Gene Aliases: DSHP; EBVS; Gm686; IMD5; LYP; MTCP1; RGD1562408; SAP; SAP/SH2D1A; SH2D1A; XLP; XLPD; XLPD1
UniProt ID: (Human) O60880, (Rat) B2RZ59, (Mouse) O88890
Entrez Gene ID: (Human) 4068, (Rat) 501502, (Mouse) 20400
adaptive immune response
immune system process
humoral immune response
cellular defense response
cell-cell signaling
natural killer cell activation
natural killer cell mediated cytotoxicity
innate immune response
positive regulation of natural killer cell mediated cytotoxicity
regulation of immune response
negative regulation of T cell receptor signaling pathway
biological_process
positive regulation of signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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