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Proteintech
SH3BP1 Polyclonal Antibody
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Product Details
20541-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SH3BP1 Fusion Protein Ag14575 (1-350 aa encoded by BC008282)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Amount
58.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAESFKELD PDSSMGKALE MSCAIQNQLA RILAEFEMTL ERDVLQPLSR LSEEELPAIL KHKKSLQKLV SDWNTLKSRL SQATKNSGSS QGLGGSPGSH SHTTMANKVE TLKEEEEELK RKVEQCRDEY LADLYHFVTK EDSYANYFIR LLEIQADYHR RSLSSLDTAL AELRENHGQA DHSPSMTATH FPRVYGVSLA THLQELGREI ALPIEACVMM LLSEGMKEEG LFRLAAGASV LKRLKQTMAS DPHSLEEFCS DPHAVAGALK SYLRELPEPL MTFDLYDDWM RAASLKEPGA RLQALQEVCS RLPPENLSNL RYLMKFLARL AEEQEVNKMT PSNIAIVLGP N (1-350 aa encoded by BC008282)
Target Information
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3BP-1; OTTHUMP00000028981; SH3 domain-binding protein 1; SH3BP1; unnamed protein product
Gene Aliases: 3BP-1; 3bp1; ARHGAP43; SH3BP1
UniProt ID: (Human) Q9Y3L3, (Mouse) P55194
Entrez Gene ID: (Human) 23616, (Mouse) 20401
phagocytosis
phagocytosis, engulfment
actin filament organization
signal transduction
cell migration
regulation of actin filament depolymerization
regulation of actin cytoskeleton organization
cell junction assembly
regulation of Rac protein signal transduction
regulation of blood vessel endothelial cell migration
positive regulation of GTPase activity
establishment of epithelial cell apical/basal polarity
regulation of small GTPase mediated signal transduction
negative regulation of small GTPase mediated signal transduction
semaphorin-plexin signaling pathway
ruffle assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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