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Immunogen sequence: MAESFKELD PDSSMGKALE MSCAIQNQLA RILAEFEMTL ERDVLQPLSR LSEEELPAIL KHKKSLQKLV SDWNTLKSRL SQATKNSGSS QGLGGSPGSH SHTTMANKVE TLKEEEEELK RKVEQCRDEY LADLYHFVTK EDSYANYFIR LLEIQADYHR RSLSSLDTAL AELRENHGQA DHSPSMTATH FPRVYGVSLA THLQELGREI ALPIEACVMM LLSEGMKEEG LFRLAAGASV LKRLKQTMAS DPHSLEEFCS DPHAVAGALK SYLRELPEPL MTFDLYDDWM RAASLKEPGA RLQALQEVCS RLPPENLSNL RYLMKFLARL AEEQEVNKMT PSNIAIVLGP N (1-350 aa encoded by BC008282)
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3BP-1; OTTHUMP00000028981; SH3 domain-binding protein 1; SH3-domain binding protein 1
Gene Aliases: 3BP-1; 3bp1; ARHGAP43; SH3BP1
UniProt ID: (Human) Q9Y3L3, (Mouse) P55194
Entrez Gene ID: (Human) 23616, (Mouse) 20401
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