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Immunohistochemical staining of paraffin embedded lymphocytes in the interstitial parenchyma of the kidney (top) and in a glomerulus of the kidney (bottom) using PA5-18249 at concetration of 0.3 ug/ml. The tissue was processed by microwaved antigen retrieval with citrate buffer pH 6 and stained with HRP.
|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (PQPRPRSLASETN) corresponding to the C-terminus amino acids of SH3BP1|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||0.3 µg/ml|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
3BP-1; OTTHUMP00000028981; SH3 domain binding protein 1; SH3-domain binding protein 1; SH3BP1