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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 65 and 275 of Human SH3BP1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-30483 targets SH3BP1 in WB applications and shows reactivity with Human samples.
The PA5-30483 immunogen is recombinant protein fragment corresponding to a region within amino acids 65 and 275 of Human SH3BP1.
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
3BP-1; ARHGAP43; SH3 domain binding protein 1; SH3 domain-binding protein 1; SH3-domain binding protein 1