This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.
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Protein Aliases: c-Cbl-interacting protein; Cbl-interacting protein of 85 kDa; CD2-binding protein 3; CD2BP3; HSB-1; Human Src family kinase-binding protein 1; migration-inducing gene 18; Regulator of ubiquitous kinase; Ruk; SH3 domain-containing adapter protein; SH3 domain-containing kinase-binding protein 1; SH3-containing, expressed in tumorigenic astrocytes; SH3-domain kinase binding protein 1; Src family kinase-binding protein 1; src-related kinase binding protein-1
Gene Aliases: 1200007H22Rik; 1700125L08Rik; 5830464D22Rik; AI447724; CD2BP3; CIN85; GIG10; HSB-1; HSB1; IN85; MIG18; Ruk; Seta; SH3KBP1