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Invitrogen
SHANK1 Polyclonal Antibody
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Product Details
PA5149727
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SHANK1
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TVKASIISEL SSKLQQFGGS SAAGGALPWA RGGSGGGGDS HHGGASYVPE RTSSLQRQRL SDDSQSSLLS KPVSSLFQNW PKPPLP
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 91%.
Target Information
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: multidomain postsynaptic density protein; OTTHUMP00000174437; postsynaptic scaffold protein; SH3 and multiple ankyrin repeat domains protein 1; SHANK 1; Shank1; Somatostatin receptor-interacting protein; SPANK 1; SSTR-interacting protein
Gene Aliases: SHANK1; SPANK-1; SSTRIP; synamon
UniProt ID: (Human) Q9Y566
Entrez Gene ID: (Human) 50944
G-protein coupled receptor binding
protein binding
SH3 domain binding
receptor signaling complex scaffold activity
GKAP/Homer scaffold activity
somatostatin receptor binding
ionotropic glutamate receptor binding
identical protein binding
macromolecular complex binding
ankyrin repeat binding
scaffold protein binding
structural constituent of postsynaptic density
nervous system development
long-term memory
associative learning
cell differentiation
adult behavior
negative regulation of actin filament bundle assembly
social behavior
protein localization to synapse
olfactory behavior
habituation
modulation of synaptic transmission
synapse organization
neuromuscular process controlling balance
cognition
determination of affect
righting reflex
synapse maturation
dendritic spine morphogenesis
positive regulation of dendritic spine development
protein-containing complex assembly
vocalization behavior
AMPA selective glutamate receptor signaling pathway
maintenance of postsynaptic density structure
positive regulation of excitatory postsynaptic potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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