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      SHANK3 Polyclonal Antibody

      See 1 other SHANK3 antibodies ›
      SHANK3 Polyclonal Antibody for Western Blot, IF, ICC and IHC

      Catalog#: PA5-34383 Invitrogen

      Catalog # Size Price (USD) Qty Datasheet
      PA5-34383 100 ug
      349.00
      Please enter a quantity in the range of 1 to 199.
      Suggested Secondary Antibodies

      Anti-Rabbit Secondary Antibodies (264)
      Alexa Fluor® Anti-Rabbit Secondary Antibodies (69)
      HRP Anti-Rabbit Secondary Antibodies (30)

      Product Details

      Bioinformatics

      Documents
      Details
      Tested species reactivity Human, Mouse
      Host / Isotype Rabbit / IgG
      Class Polyclonal
      Type Antibody
      Immunogen A 19 amino acid synthetic peptide near the center of human SHANK3
      Conjugate Unconjugated
      Form Liquid
      Concentration 1 mg/ml
      Purification Antigen affinity chromatography
      Storage buffer PBS
      Contains 0.02% sodium azide
      Storage Conditions Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
      Tested Applications Dilution *
      Immunocytochemistry (ICC) 20 ug/ml
      Immunofluorescence (IF) 2.5 ug/mL
      Immunohistochemistry (IHC) 2.5 ug/mL
      Western Blot (WB) 1 ug/mL

      * Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

      Product Specific Information

      A suggested positive control is NIH-3T3 cell lysate.

      PA5-34383 can be used with blocking peptide PEP-1426.

      Background/Target Information

      SH3 and multiple ankyrin repeat domains 3 (SHANK3), a member of the Shank gene family, plays a role in synapse formation and dendritic spine maturation. Shank proteins (Shank 1-3) containing PDZ domains are scaffold proteins of the postsynaptic density (PSD) that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder (ASD) and the neurological symptoms of 22q13.3 deletion syndrome.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      Bioinformatics

      Protein Aliases:

      proline rich synapse associated protein 2; Proline-rich synapse-associated protein 2; ProSAP2; PSAP2; SH3 and multiple ankyrin repeat domains 3; SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains protein 3 variant c-3; SH3 and multiple ankyrin repeat domains protein 3 variant c-4; SH3 and multiple ankyrin repeat domains-like protein 3 variant 1; SH3 and multiple ankyrin repeat domains-like protein 3 variant 2; SH3 and multiple ankyrin repeat domains-like protein 3 variant 3; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-3; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-2; shank postsynaptic density protein; SHANK3; shank3 splice variant II; shank3 splice variant III; shank3 splice variant IV; shank3e splice variant III; shank3e splice variant IV; SPANK-2

      Gene Aliases:

      AI841104; DEL22q13.3; KIAA1650; PROSAP2; PSAP2; SCZD15; SHANK3; Shank3b; SHANK3c-3; SHANK3c-4; SPANK-2

      UniProt ID:

      (Human) Q9BYB0, (Mouse) Q4ACU6

      Entrez Gene ID:

      (Human) 85358, (Mouse) 58234

      Function(s) Process(es)

      Documents

      Material safety data sheets (MSDS)

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