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Invitrogen
SHIP2 Polyclonal Antibody
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FIGURE: 1 / 1
SHIP2 Antibody (PA5-87643) in WB
Western blot analysis of SHIP2 in extracts of various cell lines. Samples were incubated with SHIP2 Polyclonal antibody (Product # PA5-87643) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-87643
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-310 of human INPPL1 (NP_0015583)
Conjugate
Form
Liquid
Concentration
1.72 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GLYAQPNQGL VCALLLPVEG EREPDPPDDR DASDGEDEKP PLPPRSGSTS ISAPTGPSSP LPAPETPTAP AAESAPNGLS TVSHDYLKGS YGLDLEAVRG GASHLPHLTR TLATSCRRLH SEVDKVLSGL EILSKVFDQQ SSPMVTRLLQ QQNLPQTGEQ ELESLVLKLS VLKDFLSGIQ KKALKALQDM SSTAPPAPQP STRKAKTIPV Q; Positive Samples: HeLa, U-251MG, A-549, BT-474, Mouse heart, Mouse brain, Rat brain; Cellular Location: Cell projection, Cytoplasm, Membrane, Peripheral membrane protein, cytoskeleton, cytosol, filopodium, lamellipodium
Target Information
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodeling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 51C protein; ablSH3-binding protein; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; NS1; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; Protein 51C; PTP2C; SH-PTP2; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SH2-containing inositol phosphatase 2; SHIP-2; SHP-2
Gene Aliases: 51C; INPPL1; OPSMD; SHIP2
UniProt ID: (Human) O15357, (Rat) Q9WVR3, (Mouse) Q6P549
Entrez Gene ID: (Human) 3636, (Rat) 65038, (Mouse) 16332
establishment of mitotic spindle orientation
endochondral ossification
immune system process
glucose metabolic process
lipid metabolic process
phosphatidylinositol biosynthetic process
endocytosis
apoptotic process
actin filament organization
cell adhesion
negative regulation of cell proliferation
post-embryonic development
gene expression
negative regulation of gene expression
response to insulin
regulation of protein localization
protein kinase B signaling
negative regulation of insulin-like growth factor receptor signaling pathway
phosphatidylinositol dephosphorylation
regulation of immune response
ERK1 and ERK2 cascade
ruffle assembly
regulation of actin filament organization
brain development
negative regulation of DNA replication
negative regulation of platelet-derived growth factor receptor signaling pathway
negative regulation of neuron projection development
inositol trisphosphate metabolic process
response to drug
negative regulation of MAP kinase activity
cellular lipid metabolic process
negative regulation of insulin receptor signaling pathway
dephosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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