Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: PVFPVKRRNR HSLVGPQQLG GRPAPVRRSN TMPPNLGNAG LLGRMLDEKT PPSPSGQPEE PGMVRLVCGH HNWIAVAYTQ FLVCYRLKEA
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 94%.
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: SETA-binding protein 1; SH3KBP1-binding protein 1
Gene Aliases: PP203; SB1; SHKBP1
UniProt ID: (Human) Q8TBC3
Entrez Gene ID: (Human) 92799
Molecular Function: scaffold/adaptor protein
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