Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This antibody can detect both 49 kDa and 53 kDa isoforms in western blotting.
Immunogen sequence: PHGRIMGLD LPDGGHLTHG FMTDKKKISA TSIFFESMPY KVNPDTGYIN YDQLEENARL FHPKLIIAGT SCYSRNLEYA RLRKIADENG AYLMADMAHI SGLVAAGVVP SPFEHCHVVT TTTHKTLRGC RAGMIFYRKG VKSVDPKTGK EILYNLESLI NSAVFPGLQG GPHNHAIAGV AVALKQAMTL EFKVYQHQVV ANCRALSEAL TELGYKIVTG GSDNHLILVD LRSKGTDGGR AEKVLEACSI ACNKNTCPGD RSALRPSGLR LGTPALTSRG LLEKDFQKVA HFIHRGIELT LQIQSDTGVR ATLKEFKERL AGDKYQAAVQ ALREEVESFA SLFPLPGLPD F (134-483 aa encoded by BC038598)
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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