Immunogen sequence: GQLVRMAIRA QHSNAAQTQT GEANRGWTGQ ESLSDSDPEM WELLQREKDR QCRGLELIAS ENFCSRAALE AL
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 88%.
Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: epididymis secretory sperm binding protein Li 51e; GLY A+; GLYA; glycine auxotroph A; glycine auxotroph A, human complement for hamster; Glycine hydroxymethyltransferase; human complement for hamster; mitochondrial; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase; serine hydroxymethyltransferase 2 (mitochondrial); Serine hydroxymethyltransferase, mitochondrial; Serine methylase; SHMT; threonine aldolase
Gene Aliases: 2700043D08Rik; AA408223; AA986903; GLYA; HEL-S-51e; SHMT; SHMT2