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SHOX2 Polyclonal Antibody
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Product Details
OSS00307W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide to the internal region of mouse SHOX2 conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: SHOX2.
Target Information
SHOX2 is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Homeobox protein Og12X; OG-12; OGI2X; Paired family homeodomain protein Prx3; Paired-related homeobox protein SHOT; short stature homeobox 2; Short stature homeobox protein 2; SHOX homologous gene on chromosome 3; unnamed protein product
Gene Aliases: 6330543G17Rik; OG12; OG12X; Prx3; SHOT; SHOX2
UniProt ID: (Human) O60902, (Mouse) P70390, (Rat) O35750
Entrez Gene ID: (Human) 6474, (Mouse) 20429, (Rat) 25546
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
regulation of heart rate
positive regulation of mesenchymal cell proliferation
chondrocyte differentiation
chondrocyte development
sinoatrial node development
heart valve development
sinoatrial valve development
cardiac atrium morphogenesis
cardiac right atrium morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
smoothened signaling pathway
nervous system development
mesenchymal cell proliferation
embryonic limb morphogenesis
regulation of chondrocyte differentiation
embryonic forelimb morphogenesis
positive regulation of smoothened signaling pathway
embryonic digestive tract morphogenesis
embryonic morphogenesis
positive regulation of skeletal muscle fiber development
positive regulation of axonogenesis
embryonic skeletal joint morphogenesis
cartilage development involved in endochondral bone morphogenesis
muscle tissue morphogenesis
cardiac pacemaker cell differentiation
sinoatrial node cell development
stem cell proliferation
regulation of branching morphogenesis of a nerve
positive regulation of stem cell proliferation
multicellular organism development
positive regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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