Immunogen sequence: ELDMGAAERS REPGSPRLTE GRRKPTKAEV QATLLLPGEA FRFLVSPELK DRKEDAKGME DEGQTKIKQR RSRTNFTLEQ LNELERLFDE THYPDAFMRE ELSQRLGLSE ARVQVWFQNR RAKCRKQENQ LHKGVLIGAA SQFEACRVAP YVNVGALRMP FQQDSHCNVT PLSFQVQAQL QLDSAVAHAH HHLHPHLAAH APYMMFPAPP FGLPLATLAA DSASAASVVA AAAAAKTTSK NSSIADLRLK AKKHAAALGL; Positive Samples: NCI-H460, Mouse skeletal muscle, Mouse liver; Cellular Location: Nucleus
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Homeobox protein Og12X; OG-12; Paired family homeodomain protein Prx3; Paired-related homeobox protein SHOT; Short stature homeobox protein 2; SHOX homologous gene on chromosome 3
Gene Aliases: 6330543G17Rik; OG12; OG12X; Prx3; SHOT; SHOX2