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Proteintech
SHP2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
20145-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SHP2 Fusion Protein Ag13660 (1-357 aa encoded by BC008692)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTSRRWFHP NITGVEAENL LLTRGVDGSF LARPSKSNPG DFTLSVRRNG AVTHIKIQNT GDYYDLYGGE KFATLAELVQ YYMEHHGQLK EKNGDVIELK YPLNCADPTS ERWFHGHLSG KEAEKLLTEK GKHGSFLVRE SQSHPGDFVL SVRTGDDKGE SNDGKSKVTH VMIRCQELKY DVGGGERFDS LTDLVEHYKK NPMVETLGTV LQLKQPLNTT RINAAEIESR VRELSKLAET TDKVKQGFWE EFETLQQQEC KLLYSRKEGQ RQENKNKNRY KNILPFDHTR VVLHDGDPNE PVSDYINANI IMPEFETKCN NSKPKKSYIA TQGCLQNTVN DFWRMVFQEN SRVIVMTT (1-357 aa encoded by BC008692)
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2SH2 domain protein; encodes catalytic domain; HCP; HGNC:9644; MGC14433; Mutations: 351:OK; Noonan syndrome 1; OTTHUMP00000166108; protein tyrosine phosphatase SH-PTP2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; protein-tyrosine phosphatase SYP; PTP-1D; PTP1C; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11; SH2 domain-containing protein tyrosine phosphatase 2; SH2 domain-containing protein tyrosine phosphatase-2; SHP-2; unnamed protein product
Gene Aliases: 2700084A17Rik; BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP1D; PTP2C; SAP-2; SH-PTP2; SH-PTP3; SHP-2; SHP2; Syp
UniProt ID: (Human) Q06124, (Rat) P41499, (Mouse) P35235
Entrez Gene ID: (Human) 5781, (Rat) 25622, (Mouse) 19247
phosphotyrosine binding
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
insulin receptor binding
protein binding
protein kinase binding
receptor signaling complex scaffold activity
receptor tyrosine kinase binding
cadherin binding
cell adhesion molecule binding
peptide hormone receptor binding
binding, bridging
protein tyrosine kinase binding
protein domain specific binding
D1 dopamine receptor binding
phospholipase binding
insulin receptor substrate binding
epidermal growth factor receptor signaling pathway
brain development
heart development
fibroblast growth factor receptor signaling pathway
cytokine-mediated signaling pathway
T cell costimulation
positive regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of chondrocyte differentiation
negative regulation of type I interferon production
positive regulation of interferon-beta production
positive regulation of tumor necrosis factor production
negative regulation of cell adhesion mediated by integrin
peptidyl-tyrosine dephosphorylation
atrioventricular canal development
ERBB signaling pathway
negative regulation of T cell proliferation
vasodilation
regulation of protein complex assembly
positive regulation of ossification
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
ephrin receptor signaling pathway
genitalia development
inner ear development
negative regulation of antigen receptor-mediated signaling pathway
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
positive regulation of protein kinase B signaling
face morphogenesis
regulation of type I interferon-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to mechanical stimulus
cellular response to epidermal growth factor stimulus
positive regulation of intracellular signal transduction
negative regulation of neutrophil activation
DNA damage checkpoint
protein dephosphorylation
lipid metabolic process
triglyceride metabolic process
integrin-mediated signaling pathway
axonogenesis
hormone-mediated signaling pathway
positive regulation of signal transduction
cerebellar cortex formation
platelet formation
microvillus organization
multicellular organism growth
organ growth
megakaryocyte development
hormone metabolic process
glucose homeostasis
regulation of MAPK cascade
positive regulation of mitotic cell cycle
negative regulation of insulin secretion
regulation of protein export from nucleus
positive regulation of hormone secretion
negative regulation of hormone secretion
platelet-derived growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
smooth muscle cell proliferation
homeostasis of number of cells within a tissue
negative regulation of cortisol secretion
positive regulation of focal adhesion assembly
Bergmann glial cell differentiation
negative regulation of growth hormone secretion
intestinal epithelial cell migration
cellular response to hydrogen peroxide
cellular response to angiotensin
cellular response to insulin-like growth factor stimulus
regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of type I interferon production
regulation of tumor necrosis factor production
regulation of cell adhesion mediated by integrin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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