This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 83%
SHQ1 is the human homolog of yeast Shq1p, a protein that acts as an accessory factor in the assembly of H/ACA ribonucleoproteins. SHQ1 has been shown to bind the major H/ACA core protein and the pseudouridine synthase NAP57, but precedes the assembly role of NAF1 and of the other H/ACA core proteins. SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase.
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Protein Aliases: FLJ10539; gene associated with retinoid and interferon-induced mortality 1; Protein SHQ1 homolog; SHQ1; SHQ1 homolog; SHQ1 homolog (S. cerevisiae); Shq1p
Gene Aliases: 2810403P18Rik; BOS_20841; GRIM-1; RGD1310610; SHQ1; Shq1p