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Invitrogen
SIGLEC11 Polyclonal Antibody
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FIGURE: 1 / 1
SIGLEC11 Antibody (PA5-48029) in Flow
Flow cytometry of SIGLEC11 in Human peripheral blood monocytes (PBMC). Samples were labeled with SIGLEC11 polyclonal antibody (Product # PA5-48029) followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody and Human CD14 APC-conjugated Monoclonal Antibody. Quadrant markers were set based on control antibody staining.
Product Details
PA5-48029
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant human Siglec-11 Asn17-His543 (Glu84Ala, Lys145Gln)
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISA and Western blots, approximately 20% cross-reactivity with recombinant human (rh) Siglec-10 is observed and less than 5% cross-reactivity with rhSiglec-2, -3, -5, -6, -7, -9 and recombinant mouse Siglec-F is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Siglecs are sialic acid-binding lectins of the immunoglobulin superfamily that are mainly expressed in cells of the hematopoietic system. Siglec11 is unlike other siglecs in that it binds specifically to alpha2-8-linked sialic acids and is not found in peripheral blood leukocytes but instead on macrophages of various tissues. Siglec11 is highly homologous to Siglec10 over their extracellular domain but not over their cytoplasmic domain, suggesting that Siglec11 arose through gene duplication followed by a recombination event involving another ancestral siglec gene. Following treatment of Siglec11-transfected cells with pervanadate, Siglec11 becomes tyrosine-phosphorylated and strongly associates with SHP-1 and SHP-2. At least five isoforms of Siglec11 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: immunoglobulin superfamily; Sialic acid-binding Ig-like lectin 11; Sialic acid-binding lectin 11; Siglec; siglec-11
Gene Aliases: SIGLEC11; UNQ9222/PRO28718
UniProt ID: (Human) Q96RL6
Entrez Gene ID: (Human) 114132
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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