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Proteintech
SIK2 Polyclonal Antibody
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Product Details
27608-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SIK2 fusion protein Ag26468
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: VQLLYEQIGP EADPNLAPAA PQLQDLASSC PQEEVSQQQE SVSTLPASVH PQLSPRQSLE TQYLQHRLQK PSLLSKAQNT CQLYCKEPPR SLEQQLQEHR LQQKRLFLQK QSQLQAYFNQ MQIAESSYPQ PSQQLPLPRQ ETPPPSQQAP PFSLTQPLSP VLEPSSEQMQ YSPFLSQYQE MQLQPLPSTS GPRAAPPLPT QLQQQQPPPP PPPPPPRQPG AAPAPLQFSY QTCELPSAAS PAPDYPTPCQ YPVDGAQQSD LTGPDCPRSP GLQEAPSSYD PLALSELPGL FDCEMLDAVD PQHNGYVLVN
Target Information
SNF1LK2 (QIK) is a serine/threonine kinase and is a salt-inducible kinase that belongs to the AMP-activated protein kinase family. SNF1LK2 negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1'alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Qin-induced kinase; Salt-inducible kinase 2; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SNF1-like kinase 2
Gene Aliases: KIAA0781; LOH11CR1I; QIK; SIK-2; SIK2; SNF1LK2
UniProt ID: (Human) Q9H0K1
Entrez Gene ID: (Human) 23235
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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