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Proteintech
SIPA1L1 Polyclonal Antibody
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Product Details
25086-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SIPA1L1 Fusion Protein Ag18900 (1454-1803 aa encoded by BC146777)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SQLAPSFSS SSSSSSGPRS FYPRQGATSK YLIGWKKPEG TINSVGFMDT RKRHQSDGNE IAHTRLRAST RDLRASPKPT SKSTIEEDLK KLIDLESPTP ESQKSFKFHA LSSPQSPFPS TPTSRRALHR TLSDESIYNS QREHFFTSRA SLLDQALPND VLFSSTYPSL PKSLPLRRPS YTLGMKSLHG EFSASDSSLT DIQETRRQPM PDPGLMPLPD TAADLDWSNL VDAAKAYEVQ RASFFAASDE NHRPLSAASN SDQLEDQALP QMKPYSSKDS SPTLASKVDQ LEGMLKMLRE DLKKEKEDKA HLQAEVQHLR EDNLRLQEES QNASDKLKKF TEWVFNTIDM S (1454-1803 aa encoded by BC146777)
Target Information
Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E6-targeted protein 1; H_DJ1140G11.1; High-risk human papilloma viruses E6 oncoproteins targeted protein 1; signal-induced proliferation-associated 1 like 1; Signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; SPA-1 like protein p1294; SPA-1-like protein p1294; SPAR; Spine-associated Rap GTPase-activating protein; spine-associated Rap guanosine triphosphatase (GTPase) activating protein (GAP); WUGSC:H_DJ1140G11.1
Gene Aliases: 4931426N11Rik; AW213287; E6TP1; KIAA0440; mKIAA0440; SIPA1L1; Spa-1; Spa1; SPAL; Spar
UniProt ID: (Human) O43166, (Rat) O35412, (Mouse) Q8C0T5
Entrez Gene ID: (Human) 26037, (Rat) 246212, (Mouse) 217692
biological_process
actin cytoskeleton reorganization
regulation of GTPase activity
ephrin receptor signaling pathway
regulation of synaptic plasticity
regulation of axonogenesis
regulation of small GTPase mediated signal transduction
regulation of dendritic spine morphogenesis
activation of GTPase activity
positive regulation of GTPase activity
regulation of dendrite morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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