NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
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Protein Aliases: 75SirT1; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; Sir2; sir2-like 1; SIR2-like protein 1; SIR2alpha; SIRT 1; SIRT-1; SirtT1 75 kDa fragment; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1
Gene Aliases: AA673258; SIR2; Sir2a; SIR2alpha; SIR2L1; SIRT1
Molecular Function: chromatin/chromatin-binding, or -regulatory protein histone modifying enzyme