It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other sirtuin proteins.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 75SirT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; Sir2; sir2-like 1; SIR2-like protein 1; SIR2alpha; SirtT1 75 kDa fragment; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1
Gene Aliases: AA673258; Sir2; Sir2a; Sir2alpha; SIR2L1; Sirt1
UniProt ID: (Mouse) Q923E4
Entrez Gene ID: (Mouse) 93759