This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
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Protein Aliases: hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; Regulatory protein SIR2 homolog 1; Sir2; sir2-like 1; SIR2-like protein 1; SIR2alpha; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1
Gene Aliases: AA673258; SIR2; Sir2a; SIR2alpha; SIR2L1; SIRT1