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SIRT2 Polyclonal Antibody, MaxPab™

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SIRT2 Polyclonal Antibody, MaxPab™

Product Details

H00022933-B01P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SIRT2 (NP_085096.1, 1 a.a. approximately 352 a.a) full-length human protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Product may be used with Western Blot (Transfected lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MDFLRNLFSQ TLSLGSQKER LLDELTLEGV ARYMQSERCR RVICLVGAGI STSAGIPDFR SPSTGLYDNL EKYHLPYPEA IFEISYFKKH PEPFFALAKE LYPGQFKPTI CHYFMRLLKD KGLLLRCYTQ NIDTLERIAG LEQEDLVEAH GTFYTSHCVS ASCRHEYPLS WMKEKIFSEV TPKCEDCQSL VKPDIVFFGE SLPARFFSCM QSDFLKVDLL LVMGTSLQVQ PFASLISKAP LSTPRLLINK EKAGQSDPFL GMIMGLGGGM DFDSKKAYRD VAWLGECDQG CLALAELLGW KKELEDLVRR EHASIDAQSG AGVPNPSTSA SPKKSPPPAK DEARTTEREK PQ

Target Information

The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; Regulatory protein SIR2 homolog 2; silent information regulator 2; SIR2-h; SIR2-like protein 2; sir2-related protein type 2; sir2-related protein type 2; sirtuin type 2; NAD-dependent deacetylase sirtuin-2; silent information regulator 2; SIR2-like protein 2; regulatory protein SIR2; sirtuin type 2; unnamed protein product; yeast silent information regulator 2 (Sir2p) homolog

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Gene Aliases: SIR2; SIR2L; SIR2L2; SIRT2

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UniProt ID: (Human) Q8IXJ6

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Entrez Gene ID: (Human) 22933

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Function(s)
chromatin binding NAD+ ADP-ribosyltransferase activity histone deacetylase activity protein binding zinc ion binding transferase activity NAD-dependent histone deacetylase activity protein deacetylase activity NAD-dependent protein deacetylase activity histone acetyltransferase binding histone deacetylase binding tubulin deacetylase activity ubiquitin binding metal ion binding NAD-dependent histone deacetylase activity (H4-K16 specific) NAD binding NAD+ binding DNA-binding transcription factor binding NAD-dependent protein demyristoylase activity NAD-dependent protein depalmitoylase activity protein ADP-ribosylase activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin silencing at rDNA immune system process chromatin organization protein deacetylation ubiquitin-dependent protein catabolic process fatty acid biosynthetic process autophagy mitotic nuclear envelope reassembly regulation of exit from mitosis nervous system development negative regulation of autophagy negative regulation of peptidyl-threonine phosphorylation skeletal muscle satellite cell differentiation lipid catabolic process substantia nigra development myelination in peripheral nervous system cell differentiation heterochromatin assembly telomeric heterochromatin assembly regulation of myelination positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to oxidative stress peptidyl-lysine deacetylation regulation of gene expression, epigenetic negative regulation of protein catabolic process regulation of phosphorylation proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of DNA binding post-translational protein modification NLRP3 inflammasome complex assembly innate immune response regulation of fat cell differentiation negative regulation of fat cell differentiation negative regulation of fatty acid biosynthetic process positive regulation of fatty acid biosynthetic process positive regulation of meiotic nuclear division negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of lipid biosynthetic process negative regulation of developmental process regulation of multicellular organismal process cell division meiotic cell cycle regulation of cell cycle response to redox state positive regulation of cell division positive regulation of attachment of spindle microtubules to kinetochore cellular response to caloric restriction positive regulation of small molecule metabolic process negative regulation of oligodendrocyte progenitor proliferation cellular response to hypoxia cellular response to epinephrine stimulus tubulin deacetylation positive regulation of execution phase of apoptosis positive regulation of oocyte maturation negative regulation of NLRP3 inflammasome complex assembly negative regulation of satellite cell differentiation negative regulation of reactive oxygen species metabolic process
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