PA1-25472 detects SIR2 / SIRT2 from mouse samples.
PA1-25472 has been successfully used in Immunofluorescence and Western blot procedures. Predicted molucular weight of 43 kDa.
The PA1-25472 immunogen is a synthetic peptide corresponding to the C-terminal residues 722-737 of mouse SIR2/SIRT2, with a C-terminal added lysine. This sequence is 62% homologous to the corresponding human sequence.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.
The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.
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Protein Aliases: 5730427M03Rik; mSIR2L2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2; SIR2-like protein 2; Sir2l; SIR2L2; sirtuin-2
Gene Aliases: 5730427M03Rik; Sir2l; SIR2L2; Sirt2
UniProt ID: (Mouse) Q8VDQ8
Entrez Gene ID: (Mouse) 64383