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Invitrogen
SIRT3 Polyclonal Antibody
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Product Details
PA5-20971
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
A 17 amino acid peptide near the center of human SIRT3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is mouse heart tissue lysate.
PA5-20971 can be used with blocking peptide PEP-1085.
Target Information
SIRT3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The SIRT3 is included in class I of the sirtuin family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:14931; hSIRT3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; mitochondrial protein lysine deacetylase; mSIR2L3; NAD-dependent deacetylase sirtuin-3; NAD-dependent deacetylase sirtuin-3, mitochondrial; NAD-dependent protein deacetylase sirtuin-3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; NAD-dependent protein delactylase sirtuin-3; Regulatory protein SIR2 homolog 3; silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3; silent mating type information regulation 2, S.cerevisiae, homolog 3; sir2-like 3; SIR2-like protein 3; SIRT3L mitochondrial; sirtuin type 3; unnamed protein product; yeast silent information regulator 2 (Sir2p) homolog
Gene Aliases: 2310003L23Rik; AI848213; SIR2L3; SIRT3
UniProt ID: (Human) Q9NTG7, (Mouse) Q8R104
Entrez Gene ID: (Human) 23410, (Mouse) 64384, (Rat) 293615
NAD+ ADP-ribosyltransferase activity
protein binding
zinc ion binding
transferase activity
transferase activity, transferring acyl groups other than amino-acyl groups
NAD-dependent histone deacetylase activity
enzyme binding
protein deacetylase activity
NAD-dependent protein deacetylase activity
sequence-specific DNA binding
metal ion binding
NAD+ binding
NAD-dependent protein lysine delactylase activity
protein ADP-ribosylase activity
histone deacetylase activity
protein-N-terminal asparagine amidohydrolase activity
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
iprodione amidohydrolase activity
(3,5-dichlorophenylurea)acetate amidohydrolase activity
NAD-dependent histone deacetylase activity (H3-K14 specific)
4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
didemethylisoproturon amidohydrolase activity
N-isopropylacetanilide amidohydrolase activity
N-cyclohexylformamide amidohydrolase activity
isonicotinic acid hydrazide hydrolase activity
cis-aconitamide amidase activity
gamma-N-formylaminovinylacetate hydrolase activity
N2-acetyl-L-lysine deacetylase activity
O-succinylbenzoate synthase activity
indoleacetamide hydrolase activity
N-acetylcitrulline deacetylase activity
N-acetylgalactosamine-6-phosphate deacetylase activity
NAD binding
diacetylchitobiose deacetylase activity
chitooligosaccharide deacetylase activity
protein deacetylation
aerobic respiration
positive regulation of insulin secretion
cellular response to stress
peptidyl-lysine deacetylation
negative regulation of ERK1 and ERK2 cascade
positive regulation of superoxide dismutase activity
positive regulation of catalase activity
positive regulation of oxidative phosphorylation
positive regulation of ceramide biosynthetic process
negative regulation of reactive oxygen species metabolic process
histone H3 deacetylation
negative regulation of peptidyl-lysine acetylation
aging
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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