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Fabgennix

SIRT3 Polyclonal Antibody, FITC

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Product Details

SIR3-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Chicken, Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide:RDLVGPFVLSPRRKDVVQLcorresponding to amino acids 203-221 of rat SIRT3 protein.

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

SIRT3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The SIRT3 is included in class I of the sirtuin family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HGNC:14931; hSIRT3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; mitochondrial protein lysine deacetylase; mSIR2L3; NAD-dependent deacetylase sirtuin-3; NAD-dependent deacetylase sirtuin-3, mitochondrial; NAD-dependent protein deacetylase sirtuin-3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; NAD-dependent protein delactylase sirtuin-3; Regulatory protein SIR2 homolog 3; silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3; silent mating type information regulation 2, S.cerevisiae, homolog 3; sir2-like 3; SIR2-like protein 3; SIRT3L mitochondrial; sirtuin type 3; unnamed protein product; yeast silent information regulator 2 (Sir2p) homolog

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Gene Aliases: 2310003L23Rik; AI848213; SIR2L3; SIRT3; sirtuin

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UniProt ID: (Human) Q9NTG7, (Mouse) Q8R104

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Entrez Gene ID: (Human) 23410, (Chicken) 422988, (Mouse) 64384, (Rat) 293615

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Function(s)
NAD+ ADP-ribosyltransferase activity protein binding zinc ion binding transferase activity transferase activity, transferring acyl groups other than amino-acyl groups NAD-dependent histone deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity sequence-specific DNA binding metal ion binding NAD+ binding NAD-dependent protein lysine delactylase activity protein ADP-ribosylase activity histone deacetylase activity protein-N-terminal asparagine amidohydrolase activity UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides iprodione amidohydrolase activity (3,5-dichlorophenylurea)acetate amidohydrolase activity NAD-dependent histone deacetylase activity (H3-K14 specific) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity didemethylisoproturon amidohydrolase activity N-isopropylacetanilide amidohydrolase activity N-cyclohexylformamide amidohydrolase activity isonicotinic acid hydrazide hydrolase activity cis-aconitamide amidase activity gamma-N-formylaminovinylacetate hydrolase activity N2-acetyl-L-lysine deacetylase activity O-succinylbenzoate synthase activity indoleacetamide hydrolase activity N-acetylcitrulline deacetylase activity N-acetylgalactosamine-6-phosphate deacetylase activity NAD binding diacetylchitobiose deacetylase activity chitooligosaccharide deacetylase activity
Process(es)
protein deacetylation aerobic respiration positive regulation of insulin secretion cellular response to stress peptidyl-lysine deacetylation negative regulation of ERK1 and ERK2 cascade positive regulation of superoxide dismutase activity positive regulation of catalase activity positive regulation of oxidative phosphorylation positive regulation of ceramide biosynthetic process negative regulation of reactive oxygen species metabolic process histone H3 deacetylation negative regulation of peptidyl-lysine acetylation aging
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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