|Western Blot (WB)||Assay dependent|
|Tested Species reactivity||Bovine, Dog, Human, Mouse, Pig, Rat|
|Host / Isotype||Goat / IgG|
|Immunogen||synthetic peptide SRCGELLPLIDPC.|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-31010 detects SIRT4 from human samples. Expected to cross-react with mouse and rat samples due to sequence homology.
PA1-31010 has been successfully used in Western blot applications. PA1-31010 detects a band of ~40 kDa in human kidney and U937 lysates.
The PA1-31010 immunogen is: Synthetic peptide: SRCGELLPLIDPC.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC130046; MGC130047; MGC57437; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent deacetylase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Regulatory protein SIR2 homolog 4; sir2-like 4; SIR2-like protein 4; SIR2L4; SIRT4; sirtuin type 4
Gene Aliases: 4930596O17Rik; BOS_16541; SIR2L4; SIRT4
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