This antibody is predicted to react with bovine, canine, mouse and porcine based on sequence homology.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC130046; MGC130047; MGC57437; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Regulatory protein SIR2 homolog 4; sir2-like 4; SIR2-like protein 4; SIR2L4; SIRT4; sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae); sirtuin 4; sirtuin silent mating type information regulation 2 homolog 4 (S. cerevisiae); sirtuin type 4
Gene Aliases: SIR2L4; SIRT4
UniProt ID: (Human) Q9Y6E7