Immunogen sequence: IGLFVPASPP LDPEKVKELQ RFITLSKRLL VMTGAGISTE SGIPDYRSEK VGLYARTDRR PIQHGDFVRS APIRQRYWAR NFVGWPQFSS HQPNPAHWAL STWEKLGKLY WLVTQNVDAL HTKAGSRRLT ELHGCMDRVL CLDCGEQTPR GVLQERFQVL NPTWSAEAHG LAPDGDVFLS EEQVRSFQVP TCVQCGGHLK PDVVFFGDTV NPDKVDFVHK RVKEADSLLV VG; Positive Samples: Mouse liver, Mouse heart, Rat lung; Cellular Location: Mitochondrion matrix
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Protein Aliases: MGC130046; MGC130047; MGC57437; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Regulatory protein SIR2 homolog 4; SIR2-like protein 4
Gene Aliases: 4930596O17Rik; Sir2l4; Sirt4
UniProt ID: (Mouse) Q8R216