Invitrogen

SIRT4 Polyclonal Antibody

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SIRT4 Polyclonal Antibody

Product Details

PA5-96727

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-

Affinity Purification (AP)

-
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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

C. elegans

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 29-313 of human SIRT4 (NP_0363721)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

6.79 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808529

Product Specific Information

Positive Samples: Mouse liver, Mouse heart, Rat lung; Cellular Location: Mitochondrion matrix

Immunogen sequence: IGLFVPASPP LDPEKVKELQ RFITLSKRLL VMTGAGISTE SGIPDYRSEK VGLYARTDRR PIQHGDFVRS APIRQRYWAR NFVGWPQFSS HQPNPAHWAL STWEKLGKLY WLVTQNVDAL HTKAGSRRLT ELHGCMDRVL CLDCGEQTPR GVLQERFQVL NPTWSAEAHG LAPDGDVFLS EEQVRSFQVP TCVQCGGHLK PDVVFFGDTV NPDKVDFVHK RVKEADSLLV VGSSLQVYSG YRFILTAWEK KLPIAILNIG PTRSDDLACL KLNSRCGELL PLIDP

Target Information

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: MGC130046; MGC130047; MGC57437; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein biotinylase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Regulatory protein SIR2 homolog 4; sir2-like 4; SIR2-like protein 4; SIRT4; sirtuin type 4

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Gene Aliases: 4930596O17Rik; SIR2L4; SIRT4

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UniProt ID: (Human) Q9Y6E7, (Mouse) Q8R216

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Entrez Gene ID: (Human) 23409, (Mouse) 75387, (Rat) 304539

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Function(s)
NAD+ ADP-ribosyltransferase activity protein binding zinc ion binding NAD-dependent protein deacetylase activity biotinidase activity lipoamidase activity NAD+ binding imidazoleglycerol-phosphate synthase activity histone deacetylase activity protein-N-terminal asparagine amidohydrolase activity UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity transferase activity hydrolase activity NAD(P)-cysteine ADP-ribosyltransferase activity NAD(P)-asparagine ADP-ribosyltransferase activity NAD(P)-serine ADP-ribosyltransferase activity iprodione amidohydrolase activity (3,5-dichlorophenylurea)acetate amidohydrolase activity 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity didemethylisoproturon amidohydrolase activity N-isopropylacetanilide amidohydrolase activity N-cyclohexylformamide amidohydrolase activity isonicotinic acid hydrazide hydrolase activity cis-aconitamide amidase activity gamma-N-formylaminovinylacetate hydrolase activity N2-acetyl-L-lysine deacetylase activity O-succinylbenzoate synthase activity indoleacetamide hydrolase activity 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity N-acetylcitrulline deacetylase activity purine deoxyribosyltransferase activity metal ion binding N-acetylgalactosamine-6-phosphate deacetylase activity diacetylchitobiose deacetylase activity chitooligosaccharide deacetylase activity molecular_function
Process(es)
protein ADP-ribosylation glutamine metabolic process cellular response to DNA damage stimulus negative regulation of cardiac muscle cell apoptotic process peptidyl-lysine deacetylation negative regulation of fatty acid oxidation negative regulation of insulin secretion positive regulation of lipid biosynthetic process tricarboxylic acid metabolic process negative regulation of protein processing involved in protein targeting to mitochondrion regulation of glutamine family amino acid metabolic process chromatin silencing cellular response to hypoxia regulation of pyruvate dehydrogenase activity
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