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SIRT5 Polyclonal Antibody
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Product Details
BS-9456R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SIRT5, amino acids 120-170.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ36950; NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03160}; Regulatory protein SIR2 homolog 5; regulatory protein SIR2 homolog 5 {ECO:0000255|HAMAP-Rule:MF_03160}; silent mating type information regulation 2, S.cerevisiae, homolog 5; sir2-like 5; SIR2-like protein 5; SIR2-like protein 5 {ECO:0000255|HAMAP-Rule:MF_03160}; sirtuin type 5; unnamed protein product; yeast silent information regulator 2 (Sir2p) homolog; similar to prokaryotic sirtuins
Gene Aliases: 0610012J09Rik; 1500032M05Rik; AV001953; SIR2L5; SIRT5
UniProt ID: (Human) Q9NXA8, (Mouse) Q8K2C6, (Rat) Q68FX9
Entrez Gene ID: (Human) 23408, (Mouse) 68346, (Rat) 306840
NAD+ ADP-ribosyltransferase activity
zinc ion binding
transferase activity
transferase activity, transferring acyl groups other than amino-acyl groups
NAD-dependent histone deacetylase activity
NAD-dependent protein deacetylase activity
protein-malonyllysine demalonylase activity
protein-succinyllysine desuccinylase activity
metal ion binding
protein-glutaryllysine deglutarylase activity
NAD+ binding
protein ADP-ribosylase activity
histone deacetylase activity
protein binding
protein-N-terminal asparagine amidohydrolase activity
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
hydrolase activity
iprodione amidohydrolase activity
(3,5-dichlorophenylurea)acetate amidohydrolase activity
4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
didemethylisoproturon amidohydrolase activity
N-isopropylacetanilide amidohydrolase activity
N-cyclohexylformamide amidohydrolase activity
isonicotinic acid hydrazide hydrolase activity
cis-aconitamide amidase activity
gamma-N-formylaminovinylacetate hydrolase activity
N2-acetyl-L-lysine deacetylase activity
O-succinylbenzoate synthase activity
indoleacetamide hydrolase activity
N-acetylcitrulline deacetylase activity
N-acetylgalactosamine-6-phosphate deacetylase activity
diacetylchitobiose deacetylase activity
chitooligosaccharide deacetylase activity
molecular_function
negative regulation of cardiac muscle cell apoptotic process
peptidyl-lysine demalonylation
protein desuccinylation
peptidyl-lysine desuccinylation
negative regulation of reactive oxygen species metabolic process
response to ischemia
protein deacetylation
mitochondrion organization
regulation of ketone biosynthetic process
response to nutrient levels
protein demalonylation
protein deglutarylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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