Proteintech

SIRT6 Polyclonal Antibody

SIRT6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SIRT6 Antibody (13572-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human brain using 13572-1-AP (SIRT6 antibody) at dilution of 1:50 (under 40x lens).

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Product Details

13572-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 25 publications 25 publications

Immunohistochemistry (IHC)

View 12 publications 12 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunocytochemistry (ICC/IF)

View 8 publications 8 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SIRT6 Fusion Protein Ag4469 (1-328 aa encoded by BC028220)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against full length human SIRT6 antigen.

Immunogen sequence: MSVNYAAGL SPYADKGKCG LPEIFDPPEE LERKVWELAR LVWQSSNVVF HTGAGISTAS GIPDFRGPHG VWTMEERGLA PKFDTTFESA RPTQTHMALV QLERVGLLRF LVSQNVDGLH VRSGFPRDKL AELHGNMFVE ECAKCKTQYV RDTVVGTMGL KATGRLCTVA KARGLRACRN ADLSITLGTS LQIRPSGNLP LATKRRGGRL VIVNLQPTKH DRHADLRIHG YVDEVMTRLM KHLGLEIPAW DGPRVLERAL PPLPRPPTPK LEPKEESPTR INGSIPAGPK QEPCAQHNGS EPASPKRERP TSPAPHRPPK RVKAKAVPS (1-328 aa encoded by BC028220 )

Target Information

Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in human aging.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Immunoexpression of SIRT1, 6, and 7 in oral leukoplakia and oral squamous cell carcinoma.

Odontology

Sripodok P,Saito H,Kouketsu A,Takahashi T,Kumamoto H

Mon Jan 01 00:00:00 UTC 2024

Xiaojianzhong decoction prevents gastric precancerous lesions in rats by inhibiting autophagy and glycolysis in gastric mucosal cells.

World journal of gastrointestinal oncology

Zhang JX,Bao SC,Chen J,Chen T,Wei HL,Zhou XY,Li JT,Yan SG

Wed Mar 15 00:00:00 UTC 2023

SIRT6 attenuates LPS-induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling.

Immunity, inflammation and disease

Yang J,Chen X

Wed Mar 01 00:00:00 UTC 2023

Inhibition of the AKT1/mTOR pathway through SIRT6 over expression downregulated the expression of programmed death-ligand 1 and prolonged overall survival in lung adenocarcinoma.

Annals of translational medicine

Yuan ZF,Lin YD,Wu GS,Li L,Yang JP,Zhang JW

Sun Jan 15 00:00:00 UTC 2023

Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.

Diabetes

Zhou Y,Liu L,Jin B,Wu Y,Xu L,Chang X,Hu L,Wang G,Huang Y,Song L,Zhang T,Wang Y,Xiao Y,Zhang F,Shi M,Liu L,Wang T,Yan R,Guo B

Mon May 01 00:00:00 UTC 2023

Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Mi Y,Wei C,Sun L,Liu H,Zhang J,Luo J,Yu X,He J,Ge H,Liu P

Sun Jan 01 00:00:00 UTC 2023

Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Mi Y,Wei C,Sun L,Liu H,Zhang J,Luo J,Yu X,He J,Ge H,Liu P

Sun Jan 01 00:00:00 UTC 2023

N⁶-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.

Nature communications

Wang X,Ding Y,Li R,Zhang R,Ge X,Gao R,Wang M,Huang Y,Zhang F,Zhao B,Liao W,Du J

Thu Mar 02 00:00:00 UTC 2023

Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery.

Antioxidants (Basel, Switzerland)

Wang Y,Cai Z,Zhan G,Li X,Li S,Wang X,Li S,Luo A

Mon Mar 13 00:00:00 UTC 2023

Hepatic SIRT6 Modulates Transcriptional Activities of FXR to Alleviate Acetaminophen-induced Hepatotoxicity.

Cellular and molecular gastroenterology and hepatology

Liu C,Pan Z,Wu Z,Tang K,Zhong Y,Chen Y,Xiao X,Guo J,Duan S,Cui T,Zhong G,Yang Z,Zhong C,Lin S,Gao Y

Mon Jul 25 00:00:00 UTC 2022

SIRT6 Activator UBCS039 Inhibits Thioacetamide-Induced Hepatic Injury In Vitro and In Vivo.

Frontiers in pharmacology

Jiao F,Zhang Z,Hu H,Zhang Y,Xiong Y

Wed Nov 01 00:00:00 UTC 2023

SIRT6 Activator UBCS039 Inhibits Thioacetamide-Induced Hepatic Injury In Vitro and In Vivo.

Frontiers in pharmacology

Jiao F,Zhang Z,Hu H,Zhang Y,Xiong Y

Wed Nov 01 00:00:00 UTC 2023

Selective transportation and energy homeostasis regulation of dietary advanced glycation end-products in human intestinal Caco-2 cells.

Food chemistry

Wu Y,Zong M,Zhang Z,Wu Y,Li L,Zhang X,Wu H,Li B

Sat Oct 15 00:00:00 UTC 2022

Selective transportation and energy homeostasis regulation of dietary advanced glycation end-products in human intestinal Caco-2 cells.

Food chemistry

Wu Y,Zong M,Zhang Z,Wu Y,Li L,Zhang X,Wu H,Li B

Sat Oct 15 00:00:00 UTC 2022

A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity.

Redox biology

Xiao M,Tang Y,Wang J,Lu G,Niu J,Wang J,Li J,Liu Q,Wang Z,Huang Z,Guo Y,Gao T,Zhang X,Yue S,Gu J

Tue Feb 01 00:00:00 UTC 2022

Reduction of H3K27cr Modification During DNA Damage in Colon Cancer.

Frontiers in oncology

Liao M,Chu W,Sun X,Zheng W,Gao S,Li D,Pei D

Tue Aug 09 00:00:00 UTC 2022

Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.

Nature communications

Lei H,Xu HZ,Shan HZ,Liu M,Lu Y,Fang ZX,Jin J,Jing B,Xiao XH,Gao SM,Gao FH,Xia L,Yang L,Liu LG,Wang WW,Liu CX,Tong Y,Wu YZ,Zheng JK,Chen GQ,Zhou L,Wu YL

Mon Jan 04 00:00:00 UTC 2021

Total Sesquiterpene Glycosides from Loquat Leaves Ameliorate HFD-Induced Insulin Resistance by Modulating IRS-1/GLUT4, TRPV1, and SIRT6/Nrf2 Signaling Pathways.

Oxidative medicine and cellular longevity

Wu R,Jian T,Ding X,Lv H,Meng X,Ren B,Li J,Chen J,Li W

Thu Feb 17 00:00:00 UTC 2022

Sirtuin 6 supra-physiological overexpression in hypothalamic pro-opiomelanocortin neurons promotes obesity via the hypothalamus-adipose axis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Tang Q,Liu Q,Yang X,Wu T,Huang C,Zhang J,Zhang Z,Zhang G,Zhao Y,Zhou J,Huang H,Xia Y,Yan J,Li Y,He J

Mon Mar 01 00:00:00 UTC 2021

Bioinformatics Analysis of the SIRT Family Members and Assessment of Their Potential Clinical Value.

OncoTargets and therapy

Liu M,Yu J,Jin H,Wang S,Ding J,Xing H,He S,Zeng Y

Fri Apr 22 00:00:00 UTC 2022

Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6-HMGB1 deacetylation.

Stem cell research & therapy

Wei W,Guo X,Gu L,Jia J,Yang M,Yuan W,Rong S

Tue Apr 13 00:00:00 UTC 2021

Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6-HMGB1 deacetylation.

Stem cell research & therapy

Wei W,Guo X,Gu L,Jia J,Yang M,Yuan W,Rong S

Tue Apr 13 00:00:00 UTC 2021

α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis.

Pharmaceutical biology

Fang C,Liu Y,Chen L,Luo Y,Cui Y,Zhang N,Liu P,Zhou M,Xie Y

Wed Dec 01 00:00:00 UTC 2021

α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis.

Pharmaceutical biology

Fang C,Liu Y,Chen L,Luo Y,Cui Y,Zhang N,Liu P,Zhou M,Xie Y

Wed Dec 01 00:00:00 UTC 2021

Kisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells.

Journal of agricultural and food chemistry

Cao Y,Hu G,Zhang Q,Ma L,Wang J,Li W,Ge Y,Cheng J,Yang Z,Fu S,Liu J

Wed Apr 14 00:00:00 UTC 2021

Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats.

Canadian journal of physiology and pharmacology

Zhang Y,Yang Z,Xu Z,Wan J,Hua T,Sun Q

Sat May 01 00:00:00 UTC 2021

BMC geriatrics

Zhao Y,Bai X,Jia X,Lu Y,Cheng W,Shu M,Zhu Y,Zhu L,Wang L,Shu Y,Song Y,Jin S

Wed Aug 04 00:00:00 UTC 2021

Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.

Scientific reports

Sivalingam K,Doke M,Khan MA,Samikkannu T

Fri Oct 29 00:00:00 UTC 2021

The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.

Cell biochemistry and function

Liu Y,Li Y,Nan LP,Wang F,Zhou SF,Wang JC,Feng XM,Zhang L

Sun Mar 01 00:00:00 UTC 2020

Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer.

Oncology letters

He Q,Chen K,Ye R,Dai N,Guo P,Wang L

Wed Apr 01 00:00:00 UTC 2020

The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer.

Frontiers in oncology

Yang Z,Huang R,Wei X,Yu W,Min Z,Ye M

Thu Oct 01 00:00:00 UTC 2020

The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats.

Connective tissue research

Liu Y,Li Y,Huang ZN,Wang ZY,Nan LP,Wang F,Zhou SF,Wang JC,Feng XM,Zhang L

Mon Jul 01 00:00:00 UTC 2019

Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.

Frontiers in genetics

Sun X,Wang S,Li Q

Thu Oct 01 00:00:00 UTC 2020

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.

Nature communications

Wang Z,Chen Z,Jiang Z,Luo P,Liu L,Huang Y,Wang H,Wang Y,Long L,Tan X,Liu D,Jin T,Wang Y,Wang Y,Liao F,Zhang C,Chen L,Gan Y,Liu Y,Yang F,Huang C,Miao H,Chen J,Cheng T,Fu X,Shi C

Mon Jun 10 00:00:00 UTC 2019

SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial-mesenchymal transition.

Cancer cell international

Yang Z,Yu W,Huang R,Ye M,Min Z

Wed Aug 23 00:00:00 UTC 2023

SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial-mesenchymal transition.

Cancer cell international

Yang Z,Yu W,Huang R,Ye M,Min Z

Wed Aug 23 00:00:00 UTC 2023

SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial-mesenchymal transition.

Cancer cell international

Yang Z,Yu W,Huang R,Ye M,Min Z

Wed Aug 23 00:00:00 UTC 2023

SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.

OncoTargets and therapy

Yu W,Yang Z,Huang R,Min Z,Ye M

Thu Oct 01 00:00:00 UTC 2020

Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma.

Oncogene

Yang H,Zhu R,Zhao X,Liu L,Zhou Z,Zhao L,Liang B,Ma W,Zhao J,Liu J,Huang G

Sat Jun 01 00:00:00 UTC 2019

Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma.

Oncogene

Yang H,Zhu R,Zhao X,Liu L,Zhou Z,Zhao L,Liang B,Ma W,Zhao J,Liu J,Huang G

Sat Jun 01 00:00:00 UTC 2019

Relationship between senescence in macaques and bone marrow mesenchymal stem cells and the molecular mechanism.

Aging

Pan XH,Chen YH,Yang YK,Zhang XJ,Lin QK,Li ZA,Cai XM,Pang RQ,Zhu XQ,Ruan GP

Wed Jan 23 00:00:00 UTC 2019

Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway.

International journal of oncology

Li N,Mao D,Cao Y,Li H,Ren F,Li K

Tue May 01 00:00:00 UTC 2018

Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway.

International journal of oncology

Li N,Mao D,Cao Y,Li H,Ren F,Li K

Tue May 01 00:00:00 UTC 2018

Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs.

Biochemical and biophysical research communications

Feng Y,Liang J,Zhai Y,Sun J,Wang J,She X,Gu Q,Liu Y,Zhu H,Luo X,Sun X

Mon Feb 19 00:00:00 UTC 2018

Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs.

Biochemical and biophysical research communications

Feng Y,Liang J,Zhai Y,Sun J,Wang J,She X,Gu Q,Liu Y,Zhu H,Luo X,Sun X

Mon Feb 19 00:00:00 UTC 2018

SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathway.

Stem cells (Dayton, Ohio)

Sun H,Wu Y,Fu D,Liu Y,Huang C

Tue Jul 01 00:00:00 UTC 2014

SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathway.

Stem cells (Dayton, Ohio)

Sun H,Wu Y,Fu D,Liu Y,Huang C

Tue Jul 01 00:00:00 UTC 2014

SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathway.

Stem cells (Dayton, Ohio)

Sun H,Wu Y,Fu D,Liu Y,Huang C

Tue Jul 01 00:00:00 UTC 2014

SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathway.

Stem cells (Dayton, Ohio)

Sun H,Wu Y,Fu D,Liu Y,Huang C

Tue Jul 01 00:00:00 UTC 2014

The effect of SIRT6 on the odontoblastic potential of human dental pulp cells.

Journal of endodontics

Sun HL,Wu YR,Huang C,Wang JW,Fu DJ,Liu YC

Sat Mar 01 00:00:00 UTC 2014

The effect of SIRT6 on the odontoblastic potential of human dental pulp cells.

Journal of endodontics

Sun HL,Wu YR,Huang C,Wang JW,Fu DJ,Liu YC

Sat Mar 01 00:00:00 UTC 2014

The effect of SIRT6 on the odontoblastic potential of human dental pulp cells.

Journal of endodontics

Sun HL,Wu YR,Huang C,Wang JW,Fu DJ,Liu YC

Sat Mar 01 00:00:00 UTC 2014

The effect of SIRT6 on the odontoblastic potential of human dental pulp cells.

Journal of endodontics

Sun HL,Wu YR,Huang C,Wang JW,Fu DJ,Liu YC

Sat Mar 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: hSIRT6; mSIRT6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacylase sirtuin-6; Protein mono-ADP-ribosyltransferase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2; SIR2 like 6; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6

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Gene Aliases: 2810449N18Rik; AI043036; SIR2L6; SIRT6

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UniProt ID: (Human) Q8N6T7, (Mouse) P59941

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Entrez Gene ID: (Human) 51548, (Mouse) 50721, (Rat) 299638

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Function(s)

Process(es)

post-embryonic cardiac muscle cell growth involved in heart morphogenesis base-excision repair protein ADP-ribosylation negative regulation of cell proliferation regulation of double-strand break repair via homologous recombination protein destabilization response to nutrient levels glucose homeostasis negative regulation of glycolytic process negative regulation of transcription, DNA-templated negative regulation of glucose import positive regulation of fibroblast proliferation histone H3-K9 modification histone H3-K9 deacetylation positive regulation of stem cell proliferation histone H3 deacetylation

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SIRT6 Polyclonal Antibody

SIRT6 Antibody (13572-1-AP) in IHC (P)

Product Details

13572-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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