PA1-16958 is specific for the ~37 kDa SIRT6 protein.
A non-specific higher molecular weight band can be seen at ~61 kDa of equal or greater intensity than the mSIRT6 band.
Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in human ageing.
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Protein Aliases: Mono-ADP-ribosyltransferase sirtuin-6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; Silent information regulator 2-like protein 6.; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6
Gene Aliases: 2810449N18Rik; AI043036; SIR2L6; SIRT6