Proteintech

SIRT7 Polyclonal Antibody

SIRT7 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SIRT7 Antibody (12994-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse heart tissue slide using 12994-1-AP (SIRT7 antibody) at dilution of 1:50 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

SIRT7 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12994-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SIRT7 Fusion Protein Ag3656 (1-400 aa encoded by BC017305)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAGGLSRS ERKAAERVRR LREEQQRERL RQVSRILRKA AAERSAEEGR LLAESADLVT ELQGRSRRRE GLKRRQEEVC DDPEELRGKV RELASAVRNA KYLVVYTGAG ISTAASIPDY RGPNGVWTLL QKGRSVSAAD LSEAEPTLTH MSITRLHEQK LVQHVVSQNC DGLHLRSGLP RTAISELHGN MYIEVCTSCV PNREYVRVFD VTERTALHRH QTGRTCHKCG TQLRDTIVHF GERGTLGQPL NWEAATEAAS RADTILCLGS SLKVLKKYPR LWCMTKPPSR RPKLYIVNLQ WTPKDDWAAL KLHGKCDDVM RLLMAELGLE IPAYSRWQDP IFSLATPLRA GEEGSHSRKS LCRSREEAPP GDRGAPLSSA PILGGWFGRG CTKRTKRKKV T (1-400 aa encoded by BC017305)

Target Information

SIRT7 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT7 is included in class IV. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT7 is included in class IV of the sirtuin family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

N⁶-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.

Nature communications

Wang X,Ding Y,Li R,Zhang R,Ge X,Gao R,Wang M,Huang Y,Zhang F,Zhao B,Liao W,Du J

Thu Mar 02 00:00:00 UTC 2023

The prognostic implications of SIRTs expression in breast cancer: a systematic review and meta-analysis.

Discover. Oncology

Zhang H,Ma C,Peng M,Lv X,Xie X,Huang R

Fri Aug 05 00:00:00 UTC 2022

A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity.

Redox biology

Xiao M,Tang Y,Wang J,Lu G,Niu J,Wang J,Li J,Liu Q,Wang Z,Huang Z,Guo Y,Gao T,Zhang X,Yue S,Gu J

Tue Feb 01 00:00:00 UTC 2022

USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.

Breast cancer research and treatment

Su Y,Wu C,Chang Y,Li L,Chen Y,Jia X,Wang X,Lv Y,Yu B,Yuan J

Tue Nov 01 00:00:00 UTC 2022

USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.

Breast cancer research and treatment

Su Y,Wu C,Chang Y,Li L,Chen Y,Jia X,Wang X,Lv Y,Yu B,Yuan J

Tue Nov 01 00:00:00 UTC 2022

USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.

Breast cancer research and treatment

Su Y,Wu C,Chang Y,Li L,Chen Y,Jia X,Wang X,Lv Y,Yu B,Yuan J

Tue Nov 01 00:00:00 UTC 2022

Data of RNA-seq transcriptomes of liver, bone, heart, kidney and blood in klotho mice at a pre-symptomatic state and the effect of a traditional Japanese multi-herbal medicine, juzentaihoto.

Data in brief

Okada N,Oshima K,Iwasaki Y,Maruko A,Matsumura K,Iioka E,Vu TD,Fujitsuka N,Nishi A,Sugiyama A,Nishiyama M,Kaneko A,Mizoguchi K,Yamamoto M,Nishimura S

Wed Jun 01 00:00:00 UTC 2022

Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells.

Aging cell

Zhang W,Yang J,Chen Y,Xue R,Mao Z,Lu W,Jiang Y

Mon Feb 01 00:00:00 UTC 2021

The effects of A549 and H1299 cell-derived exosomes on the proliferation and apoptosis of BEAS-2B cells.

Die Pharmazie

Li Z,Chen X,Yi X

Sun Aug 01 00:00:00 UTC 2021

Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine.

Gene

Okada N,Oshima K,Iwasaki Y,Maruko A,Matsumura K,Iioka E,Vu TD,Fujitsuka N,Nishi A,Sugiyama A,Nishiyama M,Kaneko A,Mizoguchi K,Yamamoto M,Nishimura S

Fri Aug 20 00:00:00 UTC 2021

Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.

Scientific reports

Sivalingam K,Doke M,Khan MA,Samikkannu T

Fri Oct 29 00:00:00 UTC 2021

Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.

Scientific reports

Sivalingam K,Doke M,Khan MA,Samikkannu T

Fri Oct 29 00:00:00 UTC 2021

Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling.

Oncology reports

Zhao Y,Ye X,Chen R,Gao Q,Zhao D,Ling C,Qian Y,Xu C,Tao M,Xie Y

Tue Sep 01 00:00:00 UTC 2020

Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling.

Oncology reports

Zhao Y,Ye X,Chen R,Gao Q,Zhao D,Ling C,Qian Y,Xu C,Tao M,Xie Y

Tue Sep 01 00:00:00 UTC 2020

Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.

Cell metabolism

Fu Y,Sun Y,Wang M,Hou Y,Huang W,Zhou D,Wang Z,Yang S,Tang W,Zhen J,Li Y,Wang X,Liu M,Zhang Y,Wang B,Liu G,Yu X,Sun J,Zhang C,Yi F

Tue Dec 01 00:00:00 UTC 2020

Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.

Frontiers in genetics

Sun X,Wang S,Li Q

Thu Oct 01 00:00:00 UTC 2020

SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-κB Signaling Pathway.

Oxidative medicine and cellular longevity

Chen KL,Li L,Li CM,Wang YR,Yang FX,Kuang MQ,Wang GL

Mon Jan 06 00:00:00 UTC 2020

SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells.

Journal of cellular physiology

Chen KL,Li L,Yang FX,Li CM,Wang YR,Wang GL

Sat Sep 01 00:00:00 UTC 2018

SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells.

Journal of cellular physiology

Chen KL,Li L,Yang FX,Li CM,Wang YR,Wang GL

Sat Sep 01 00:00:00 UTC 2018

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

Nature communications

Liu M,Liang K,Zhen J,Zhou M,Wang X,Wang Z,Wei X,Zhang Y,Sun Y,Zhou Z,Su H,Zhang C,Li N,Gao C,Peng J,Yi F

Mon Sep 04 00:00:00 UTC 2017

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

Nature communications

Liu M,Liang K,Zhen J,Zhou M,Wang X,Wang Z,Wei X,Zhang Y,Sun Y,Zhou Z,Su H,Zhang C,Li N,Gao C,Peng J,Yi F

Mon Sep 04 00:00:00 UTC 2017

MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice.

Cell death & disease

Cheng L,Zhu Y,Han H,Zhang Q,Cui K,Shen H,Zhang J,Yan J,Prochownik E,Li Y

Thu Jul 13 00:00:00 UTC 2017

MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice.

Cell death & disease

Cheng L,Zhu Y,Han H,Zhang Q,Cui K,Shen H,Zhang J,Yan J,Prochownik E,Li Y

Thu Jul 13 00:00:00 UTC 2017

An asymmetrically dimethylarginated nuclear 90 kDa protein (p90aDMA) induced by interleukin (IL)-2, IL-4 or IL-6 in the tumor microenvironment is selectively degraded by autophagy.

International journal of oncology

Sun L,Xia WY,Zhao SH,Liu N,Liu SS,Xiu P,Li LF,Cao XL,Gao JX

Wed Jun 01 00:00:00 UTC 2016

An asymmetrically dimethylarginated nuclear 90 kDa protein (p90aDMA) induced by interleukin (IL)-2, IL-4 or IL-6 in the tumor microenvironment is selectively degraded by autophagy.

International journal of oncology

Sun L,Xia WY,Zhao SH,Liu N,Liu SS,Xiu P,Li LF,Cao XL,Gao JX

Wed Jun 01 00:00:00 UTC 2016

High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.

International journal of clinical and experimental pathology

Geng Q,Peng H,Chen F,Luo R,Li R

Tue Feb 09 00:00:00 UTC 2016

High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.

International journal of clinical and experimental pathology

Geng Q,Peng H,Chen F,Luo R,Li R

Tue Feb 09 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: MGC126840; MGC126842; NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein deacylase sirtuin-7; Regulatory protein SIR2 homolog 7; silent mating type information regulation 2, S.cerevisiae, homolog 7; SIR2-like protein 7; sir2-related protein type 7; sirtuin type 7

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Gene Aliases: SIR2L7; SIRT7

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UniProt ID: (Human) Q9NRC8, (Mouse) Q8BKJ9, (Rat) B2RZ55

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Entrez Gene ID: (Human) 51547, (Mouse) 209011, (Rat) 303745

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Function(s)

Process(es)

negative regulation of transcription from RNA polymerase II promoter positive regulation of transcription involved in exit from mitosis rRNA transcription histone H3 deacetylation histone H4 deacetylation transcription, DNA-templated regulation of transcription, DNA-templated chromatin modification biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SIRT7 Polyclonal Antibody

SIRT7 Antibody (12994-1-AP) in IHC (P)

Product Details

12994-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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