The target sequence has 88% sequence homology with bovine and porcine and 82% sequence homology with drosophila.
Suggested positive control: antigen standard for SIRT7 (transient overexpression lysate), human liver protein.
SIRT7 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT7 is included in class IV. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT7 is included in class IV of the sirtuin family.
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Protein Aliases: MGC126840; MGC126842; NAD dependent deacetylase sirtuin 7; NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacetylase sirtuin-7; Regulatory protein SIR2 homolog 7; Silent mating type information regulation 2; silent mating type information regulation 2, S.cerevisiae, homolog 7; SIR2-like protein 7; sir2-related protein type 7; sirtuin type 7
Gene Aliases: SIR2L7; SIRT7