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Proteintech
SIX1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
10709-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SIX1 Fusion Protein Ag1044 (1-284 aa encoded by BC008874)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSMLPSFGF TQEQVACVCE VLQQGGNLER LGRFLWSLPA CDHLHKNESV LKAKAVVAFH RGNFRELYKI LESHQFSPHN HPKLQQLWLK AHYVEAEKLC GRPLGAVGKY RVRRKFPLPR TIWDGEETSY CFKEKSRGVL REWYAHNPYP SPREKRELAE ATGLTTTQVS NWFKNRRQRD RAAEAKEREN TENNNSSSNK QNQLSPLEGG KPLMSSSEEE FSPPQSPDQN SVLLLQGNMG HARSSNYSLP GLTASQPSHG LQTHQHQLQD SLLGPLTSSL VDLGS (1-284 aa encoded by BC008874)
Target Information
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: sine oculis homeobox homolog 1; sine oculis-related homeobox 1 homolog; six1; unnamed protein product
Gene Aliases: BOS3; DFNA23; TIP39
UniProt ID: (Human) Q15475, (Mouse) Q62231
Entrez Gene ID: (Human) 6495, (Mouse) 20471
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
metanephros development
ureteric bud development
branching involved in ureteric bud morphogenesis
cell fate specification
organ induction
kidney development
outflow tract morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
specification of segmental identity, maxillary segment
pattern specification process
skeletal muscle tissue development
sensory perception of sound
regulation of synaptic growth at neuromuscular junction
gene expression
regulation of gene expression
neural crest cell differentiation
regulation of skeletal muscle satellite cell proliferation
facial nerve morphogenesis
neurogenesis
epithelial cell differentiation
thyroid gland development
olfactory placode formation
regulation of protein localization
protein localization to nucleus
aorta morphogenesis
inner ear morphogenesis
middle ear morphogenesis
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
tongue development
regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
thymus development
neuron fate specification
generation of neurons
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
skeletal system morphogenesis
mesenchymal cell differentiation
inner ear development
regulation of epithelial cell proliferation
myoblast migration
pharyngeal system development
myotome development
fungiform papilla morphogenesis
trigeminal ganglion development
otic vesicle development
kidney mesenchyme development
metanephric mesenchyme development
nephron epithelium morphogenesis
regulation of branch elongation involved in ureteric bud branching
positive regulation of ureteric bud formation
mesonephric tubule formation
ureter smooth muscle cell differentiation
positive regulation of secondary heart field cardioblast proliferation
endothelin receptor signaling pathway
cochlea morphogenesis
regulation of branching involved in ureteric bud morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of brown fat cell differentiation
cellular response to 3,3',5-triiodo-L-thyronine
positive regulation of mesenchymal cell proliferation involved in ureter development
regulation of skeletal muscle cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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