Search
Invitrogen
SIX1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-51654
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SIX1. Recombinant protein control fragment (Product #RP-88902).
Conjugate
Form
Liquid
Concentration
0.50 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CFKEKSRGVL REWYAHNPYP SPREKRELAE ATGLTTTQVS NWFKNRRQRD RAAEAKEREN TENNNSSSNK QNQLSPLEGG KPLMSSSEEE FSPPQSPDQN SVLLLQGNMG HARSSNYSLP GLTASQPSHG LQTHQHQLQD S
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
Target Information
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Homeobox protein SIX1; Sine oculis homeobox homolog 1; six1
Gene Aliases: BOS3; DFNA23; SIX1; TIP39
UniProt ID: (Human) Q15475
Entrez Gene ID: (Human) 6495
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
branching involved in ureteric bud morphogenesis
organ induction
kidney development
outflow tract morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
Notch signaling pathway
pattern specification process
skeletal muscle tissue development
sensory perception of sound
regulation of synaptic growth at neuromuscular junction
gene expression
regulation of gene expression
neural crest cell differentiation
regulation of skeletal muscle satellite cell proliferation
regulation of skeletal muscle cell proliferation
facial nerve morphogenesis
neurogenesis
epithelial cell differentiation
thyroid gland development
olfactory placode formation
regulation of protein localization
protein localization to nucleus
aorta morphogenesis
inner ear morphogenesis
middle ear morphogenesis
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
tongue development
regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
thymus development
neuron fate specification
generation of neurons
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
skeletal system morphogenesis
skeletal muscle fiber development
inner ear development
regulation of epithelial cell proliferation
myoblast proliferation
myoblast migration
pharyngeal system development
myotome development
fungiform papilla morphogenesis
trigeminal ganglion development
otic vesicle development
metanephric mesenchyme development
regulation of branch elongation involved in ureteric bud branching
positive regulation of ureteric bud formation
mesonephric tubule formation
ureter smooth muscle cell differentiation
mesenchymal cell proliferation involved in ureter development
positive regulation of secondary heart field cardioblast proliferation
endothelin receptor signaling pathway
cochlea morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of brown fat cell differentiation
cellular response to 3,3',5-triiodo-L-thyronine
positive regulation of myoblast proliferation
positive regulation of mesenchymal cell proliferation involved in ureter development
regulation of skeletal muscle cell differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support