The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
The SIX proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Two of these family members Six3 and Six6 (also designated Optx2 and Six9) are required for the specification and proliferation of the eye field in vertebrates, and, therefore, are the vertebrate homologues most closely related to the Drosophila sine oculis protein, which has an essential role in controlling compound eye development. Six3 and Six6 expression largely overlap during development of specific tissues, such as retina, hypothalamus, and pituitary. Deletion of Six3 may be associated with HPE2 disorder, a common, severe malformation of the brain that results from incomplete cleavage of the forebrain during early embryogenesis.
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Protein Aliases: Homeobox protein SIX3; Homeobox protein SIX6; Homeodomain protein OPTX2; HPE2; Optic homeobox 2; OPTX2; Sine oculis homeobox homolog 3; Sine oculis homeobox homolog 6; sine oculis homeobox protein 6; sine oculis homeobox-like protein 3; sine oculis homeobox-like protein 6; sine oculis-related homeobox 3 homolog; sine oculis-related homeobox 6 homolog; SIX3; SIX6; SIX9; Six9 protein
Gene Aliases: E130112M24Rik; HPE2; MCOPCT2; ODRMD; OPTX2; SIX3; Six3a; Six3alpha; Six3b; Six3beta; SIX6; SIX9