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Invitrogen
SIX5 Polyclonal Antibody
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Product Details
PA5-59850
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SIX5. Recombinant protein control fragment (Product #RP-97611).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VVPTSQVVTL PQAVGPLQLL AAGPGSPVKV AAAAGPANVH LINSGVGVTA LQLPSATAPG NFLLANPVSG SPIVTGVAVQ QGKIILTATF PTSMLVSQVL P
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 90%.
Target Information
Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye. Localized to the cytoplasm in early development and to the nucleus in the later stages of development, Six5 is involved in regulation of organogenesis and in maintenance of retinal formation. Six5 is able to bind the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA. Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins. Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia. Two isoforms exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DM locus-associated homeodomain protein; dystrophia myotonica-associated homeodomain protein; Homeobox protein SIX5; Sine oculis homeobox homolog 5
Gene Aliases: BOR2; DMAHP; SIX5
UniProt ID: (Human) Q8N196
Entrez Gene ID: (Human) 147912
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
sequence-specific DNA binding
lens development in camera-type eye
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatid development
cell proliferation
negative regulation of cell proliferation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
Leydig cell proliferation
negative regulation of skeletal muscle satellite cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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