Invitrogen

SKIP Polyclonal Antibody

View all (7) SKIP antibodies

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SKIP Polyclonal Antibody

Product Details

PA5-96816

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 149-448 of human INPP5K (NP_0576162)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.51 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808618

Product Specific Information

Immunogen sequence: HLPPHISNNY QRLEHFDRIL EMQNCEGRDI PNILDHDLII WFGDMNFRIE DFGLHFVRES IKNRCYGGLW EKDQLSIAKK HDPLLREFQE GRLLFPPTYK FDRNSNDYDT SEKKRKPAWT DRILWRLKRQ PCAGPDTPIP PASHFSLSLR GYSSHMTYGI SDHKPVSGTF DLELKPLVSA PLIVLMPEDL WTVENDMMVS YSSTSDFPSS PWDWIGLYKV GLRDVNDYVS YAWVGDSKVS CSDNLNQVYI DISNIPTTED EFLLCYYSNS LRSVVGISRP FQIPPGSLRE DPLGEAQPQI; Positive Samples: Mouse brain, Rat brain; Cellular Location: Endoplasmic reticulum

Target Information

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C62; Inositol polyphosphate 5-phosphatase K; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; PI-5-phosphatase related; putative phosphoinositide 5-phosphatase type II; putative phosphoinositide 5-phosphatase type II; C62; putative PI-5-phosphatase; skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney enriched inositol polyphosphate phosphatase; Skeletal muscle and kidney-enriched inositol phosphatase

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Gene Aliases: C62; INPP5K; PPS; SKIP

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UniProt ID: (Human) Q9BT40, (Mouse) Q8C5L6

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Entrez Gene ID: (Human) 51763, (Rat) 287533, (Mouse) 19062

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Function(s)
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity vasopressin receptor activity protein binding inositol bisphosphate phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity phosphatidylinositol trisphosphate phosphatase activity phosphatidylinositol phosphate 5-phosphatase activity lipid phosphatase activity inositol trisphosphate phosphatase activity inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity molecular_function hydrolase activity phosphatase
Process(es)
in utero embryonic development negative regulation of protein phosphorylation regulation of glycogen biosynthetic process negative regulation of protein kinase activity phosphatidylinositol biosynthetic process G-protein coupled receptor signaling pathway negative regulation of peptidyl-threonine phosphorylation negative regulation of glucose transport dephosphorylation actin cytoskeleton organization cellular response to insulin stimulus cellular response to hormone stimulus negative regulation of peptidyl-serine phosphorylation negative regulation of dephosphorylation positive regulation of urine volume glucose homeostasis negative regulation of MAP kinase activity negative regulation by host of viral transcription negative regulation of glycogen biosynthetic process negative regulation of single stranded viral RNA replication via double stranded DNA intermediate negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of insulin receptor signaling pathway inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation negative regulation of stress fiber assembly negative regulation of protein kinase B signaling negative regulation of calcium ion transport cellular response to cAMP cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus protein targeting to plasma membrane negative regulation of protein targeting to membrane ruffle assembly negative regulation of glycogen (starch) synthase activity positive regulation of renal water transport biological_process response to insulin
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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