Immunogen sequence: HLPPHISNNY QRLEHFDRIL EMQNCEGRDI PNILDHDLII WFGDMNFRIE DFGLHFVRES IKNRCYGGLW EKDQLSIAKK HDPLLREFQE GRLLFPPTYK FDRNSNDYDT SEKKRKPAWT DRILWRLKRQ PCAGPDTPIP PASHFSLSLR GYSSHMTYGI SDHKPVSGTF DLELKPLVSA PLIVLMPEDL WTVENDMMVS YSSTSDFPSS PWDWIGLYKV GLRDVNDYVS YAWVGDSKVS CSDNLNQVYI DISNIPTTED EFLLCYYSNS LRSVVGISRP FQIPPGSLRE DPLGEAQPQI; Positive Samples: Mouse brain, Rat brain; Cellular Location: Endoplasmic reticulum
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified.
Protein Aliases: C62; Inositol polyphosphate 5-phosphatase K; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; PI-5-phosphatase related; putative phosphoinositide 5-phosphatase type II; putative phosphoinositide 5-phosphatase type II; C62; putative PI-5-phosphatase; skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney enriched inositol polyphosphate phosphatase; Skeletal muscle and kidney-enriched inositol phosphatase
Gene Aliases: C62; INPP5K; PPS; SKIP