Immunogen sequence: MGSLPSRRKS LPSPSLSSSV QGQGPVTMEA ERSKATAVAL GSFPAGGPAE LSLRLGEPLT IVSEDGDWWT VLSEVSGREY NIPSVHVAKV SHGWLYEGLS REKAEELLLL PGNPGGAFLI RESQTRRGSY SLSVRLSRPA SWDRIRHYRI HCLDNGWLYI; Positive Samples: K-562, A-431, HT-29; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic vesicle
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MARS; Modulator of antigen receptor signaling; SLAP-2; Src-like adapter protein 2; Src-like adapter protein-2; Src-like-adapter 2; Src-like-adaptor 2
Gene Aliases: C20orf156; MARS; SLA2; SLAP-2; SLAP2
UniProt ID: (Human) Q9H6Q3
Entrez Gene ID: (Human) 84174