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Proteintech
SLAM/CD150 Polyclonal Antibody
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Product Details
10949-2-AP
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SLAM/CD150 Fusion Protein Ag1386 (1-144 aa encoded by BC012602)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDPKGLLSL TFVLFLSLAF GASYGTGGRM MNCPKILRQL GSKVLLPLTY ERINKSMNKS IHIVVTMAKS LENSVENKIV SLDPSEAGPP RYLGDRYKFY LENLTLGIRE SRKEDEGWYL MTLEKSLHFG YLYFVLGADH DNLQT (1-144 aa encoded by BC012602)
Target Information
CD150, also known as SLAM (Signaling Lymphocyte Activation Molecule), is a member of the immunoglobulin gene superfamily and plays a crucial role in T cell stimulation and immune cell interactions. It is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells. CD150 expression is rapidly upregulated upon activation, particularly on naive T cells, Th1 cells, and activated B cells, which express the membrane-bound, soluble, and cytoplasmic isoforms of SLAM. In T cells, signaling through SLAM induces proliferation and enhances the interferon-gamma response. SLAM is also involved in adhesion between T cells and antigen-presenting cells, facilitating immune cell interactions. Homophilic SLAM-SLAM binding during B to B and B to T cell interactions is suggested to enhance the expansion and differentiation of activated B cells. CD150 serves as a receptor for the measles virus and acts as a co-activator on T and B cells. It interacts with SH2D1A and PTPN11 via its cytoplasmic domain, playing a role in signal transduction. Mutations in the CD150 gene may be associated with X-linked lymphoproliferative disease (XLP), highlighting its importance in immune regulation and disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD150; CD150 antigen; CDw150; cSLAM; IPO-3; Signaling lymphocytic activation molecule; SLAM family member 1; unnamed protein product
Gene Aliases: CD150; CDw150; IPO3; SLAM; SLAMF1
UniProt ID: (Human) Q13291
Entrez Gene ID: (Human) 6504
natural killer cell differentiation
natural killer cell proliferation
negative regulation of cytokine production
leukocyte chemotaxis involved in inflammatory response
adaptive immune response
myeloid dendritic cell activation involved in immune response
immune system process
negative regulation of T cell cytokine production
phagocytosis
immune response
cell adhesion
positive regulation of cell proliferation
positive regulation of macrophage chemotaxis
regulation of vesicle fusion
negative regulation of interferon-gamma production
negative regulation of interleukin-12 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of interferon-gamma production
positive regulation of activated T cell proliferation
innate immune response
leukocyte activation
positive regulation of JNK cascade
lymphocyte activation
viral entry into host cell
positive regulation of ERK1 and ERK2 cascade
negative regulation of CD40 signaling pathway
positive regulation of dendritic cell chemotaxis
positive regulation of T-helper 1 cell cytokine production
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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