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Proteintech
SLAMF6 Polyclonal Antibody
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Product Details
22711-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SLAMF6 Fusion Protein Ag18517 (40-332 aa encoded by BC114495)
Conjugate
Form
Liquid
Concentration
0.49 mg/mL
Amount
73.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LPLEFPAGE KVNFITWLFN ETSLAFIVPH ETKSPEIHVT NPKQGKRLNF TQSYSLQLSN LKMEDTGSYR AQISTKTSAK LSSYTLRILR QLRNIQVTNH SQLFQNMTCE LHLTCSVEDA DDNVSFRWEA LGNTLSSQPN LTVSWDPRIS SEQDYTCIAE NAVSNLSFSV SAQKLCEDVK IQYTDTKMIL FMVSGICIVF GFIILLLLVL RKRRDSLSLS TQRTQGPAES ARNLEYVSVS PTNNTVYASV THSNRETEIW TPRENDTITI YSTINHSKES KPTFSRATAL DNVV (40-332 aa encoded by BC114495)
Target Information
Ly108, the mouse homologue of human SLAMF6 (signaling lymphocyte activation molecule family member 6), is expressed on NK cells, B cells, and T cells. Engagement of the Ly108 receptor enhances NK cell activity and increases the expression of IFN-gamma. This receptor plays a role in the inability of NK cells to kill Epstein Barr virus-infected B cells in X-linked lymphoproliferative disease. In Ly108 knock-out mice, CD4+ T cells show a diminished ability to produce IL-4 and exhibit defective neutrophil functions, indicating the importance of Ly108 in immune regulation and cellular function. Overall, Ly108 is crucial for modulating immune responses and maintaining effective immune cell activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activating NK receptor; CD352; natural killer-, T- and B-cell antigen; NK-T-B-antigen; NTB-A; NTBA receptor; SLAM family member 6; unnamed protein product
Gene Aliases: CD352; KALI; KALIb; Ly108; NTB-A; NTBA; SF2000; SLAMF6; UNQ6123/PRO20080
UniProt ID: (Human) Q96DU3
Entrez Gene ID: (Human) 114836
adaptive immune response
immune system process
immune response
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
T cell activation
innate immune response
positive regulation of natural killer cell mediated cytotoxicity
T-helper 17 cell lineage commitment
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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