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Invitrogen

SLC11A2 Polyclonal Antibody

View all (19) SLC11A2 antibodies

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Product Details

PA5-87729

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.41 mg/mL

Amount

141 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804372

Product Specific Information

Positive Samples: U-87MG, LO2, SW620, NCI-H460, Mouse kidney, Mouse spleen, Mouse testis, Rat kidney, Rat testis; Cellular Location: Cell membrane, Early endosome, Endosome membrane, Mitochondrion outer membrane, Multi-pass membrane protein

Target Information

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Dct-1; Divalent cation transporter 1; Divalent metal transporter 1; DMT-1; microcytic anemia, viable anaemia; Natural resistance-associated macrophage protein 2; NRAMP 2; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; Solute carrier family 11 member 2; Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2); unnamed protein product

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Gene Aliases: AHMIO1; DCT1; DMT1; mk; NRAMP2; OK/SW-cl.20; SLC11A2; van

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UniProt ID: (Human) P49281, (Mouse) P49282, (Rat) O54902

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Entrez Gene ID: (Human) 4891, (Mouse) 18174, (Rat) 25715

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Function(s)
copper ion transmembrane transporter activity iron ion transmembrane transporter activity manganese ion transmembrane transporter activity zinc ion transmembrane transporter activity protein binding calcium ion transmembrane transporter activity cadmium ion transmembrane transporter activity cobalt ion transmembrane transporter activity ferrous iron transmembrane transporter activity lead ion transmembrane transporter activity nickel cation transmembrane transporter activity vanadium ion transmembrane transporter activity symporter activity solute:proton symporter activity inorganic cation transmembrane transporter activity cadmium ion binding metal ion transmembrane transporter activity transition metal ion transmembrane transporter activity chromium ion transmembrane transporter activity retromer complex binding transporter activity iron ion binding copper ion binding zinc ion binding hydrogen ion transmembrane transporter activity ferrous iron uptake transmembrane transporter activity nickel cation binding manganese ion binding cobalt ion binding secondary carrier transporter
Process(es)
response to hypoxia detection of oxygen porphyrin-containing compound metabolic process porphyrin-containing compound biosynthetic process heme biosynthetic process ion transport cobalt ion transport copper ion transport iron ion transport manganese ion transport cellular iron ion homeostasis learning or memory response to iron ion nickel cation transport vanadium ion transport lead ion transport metal ion transport cellular manganese ion homeostasis iron assimilation cellular response to oxidative stress iron ion transmembrane transport copper ion transmembrane transport nickel cation transmembrane transport dendrite morphogenesis erythrocyte development establishment of localization in cell transmembrane transport multicellular organismal iron ion homeostasis cadmium ion transmembrane transport manganese ion transmembrane transport zinc II ion transmembrane transport hydrogen ion transmembrane transport transition metal ion transport transport cellular copper ion homeostasis activation of cysteine-type endopeptidase activity involved in apoptotic process response to manganese ion ferrous iron transport proton transport iron ion homeostasis ferrous iron import cation transmembrane transport copper ion import into cell ferrous iron transmembrane transport response to lead ion response to cadmium ion cellular response to iron ion cellular response to tumor necrosis factor cellular response to hypoxia
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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