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This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule.
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Protein Aliases: chemokine (C-C); CKb10; MGC17134; Na-Cl cotransporter; Na-Cl symporter; NaCl electroneutral thiazide-sensitive cotransporter; NCC; NCC1; SCYA13; SCYL1; solute carrier family 12 (sodium/chloride transporter), member 3; solute carrier family 12 (sodium/chloride transporters), member 3; Solute carrier family 12 member 3; solute carrier family 12, member 3; thiazide-sensitive Na-Cl cotransporter; Thiazide-sensitive sodium-chloride cotransporter
Gene Aliases: AI035291; NCC; NCCT; SLC12A3; TSC
UniProt ID: (Human) P55017, (Rat) P55018, (Mouse) P59158
Entrez Gene ID: (Human) 6559, (Dog) 478118, (Rat) 54300, (Mouse) 20497
Molecular Function:
secondary carrier transporter
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